IL1F7 Gene Polymorphism Is not Associated with Rheumatoid Arthritis Susceptibility in the Northern Chinese Han Population : A Case-Control Study

BACKGROUND: Interleukin (IL)-37, also called IL1F7, is a natural inhibitor of inflammatory and immune responses. It is involved in the pathogenesis of rheumatoid arthritis (RA). This study aimed to investigate the role of IL1F7 gene polymorphism in RA susceptibility in a large cohort of patients.

METHODS: Five selected single-nucleotide polymorphisms in IL1F7 genes (rs2723186, rs3811046, rs4241122, rs4364030, and rs4392270) were genotyped by TaqMan Allelic Discrimination in Northern Chinese Han population. The allele and the genotype were compared between patients with RA and healthy controls. Association analyses were performed on the entire data set and on different RA subsets based on the status of the anti-cyclic citrullinated peptide antibody and the rheumatoid factor by logistic regression, adjusting for age and gender.

RESULTS: Trend associations were detected between rs2723186, rs4241122, rs4392270, and RA in Stage I (160 patients with RA; 252 healthy controls). Further validation in Stage II comprised 730 unrelated patients with RA (mean age: 54.9 ± 12.6 years; 81.6% females) and 778 unrelated healthy individuals (mean age: 53.5 ± 15.7 years; 79.5% females). No significant differences in the distributions of alleles and genotypes were observed between the case and control groups in both the entire set and the different RA subsets. Disease activity and age of RA onset were also not associated with genotype distributions.

CONCLUSION: IL1F7 gene polymorphism does not significantly influence RA susceptibility in the Northern Chinese Han population.

Medienart:

E-Artikel

Erscheinungsjahr:

2018

Erschienen:

2018

Enthalten in:

Zur Gesamtaufnahme - volume:131

Enthalten in:

Chinese medical journal - 131(2018), 2 vom: 20. Jan., Seite 171-179

Sprache:

Englisch

Beteiligte Personen:

Zhang, Xiao-Ying [VerfasserIn]
Zuo, Yu [VerfasserIn]
Li, Chun [VerfasserIn]
Tu, Xin [VerfasserIn]
Xu, Hu-Ji [VerfasserIn]
Guo, Jian-Ping [VerfasserIn]
Li, Zhan-Guo [VerfasserIn]
Mu, Rong [VerfasserIn]

Links:

Volltext

Themen:

IL37 protein, human
Interleukin-1
Journal Article

Anmerkungen:

Date Completed 17.08.2018

Date Revised 07.12.2022

published: Print

Citation Status MEDLINE

doi:

10.4103/0366-6999.222340

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM27998586X