The effects of bovine colostrum supplementation on in vivo immunity following prolonged exercise : a randomised controlled trial

BACKGROUND: Bovine colostrum (COL) has been advocated as a nutritional countermeasure to exercise-induced immune dysfunction, but there is a lack of research with clinically relevant in vivo measures.

AIM: To investigate the effects of COL supplementation on in vivo immunity following prolonged exercise using experimental contact hypersensitivity (CHS) with the novel antigen diphenylcyclopropenone (DPCP).

METHODS: In a double-blind design, 31 men were randomly assigned to COL (20 g/day) or placebo (PLA) for 58 days. Participants ran for 2 h at 60% maximal aerobic capacity on day 28 and received a primary DPCP exposure (sensitisation) 20 min after. On day 56, participants received a low-dose-series DPCP challenge to elicit recall of in vivo immune-specific memory (quantified by skinfold thickness 24 and 48 h later). Analysis of the dose-response curves allowed determination of the minimum dose required to elicit a positive response (i.e., sensitivity).

RESULTS: There was no difference in summed skinfold thickness responses between COL and PLA at 24 h (p = 0.124) and 48 h (p = 0.405). However, sensitivity of in vivo immune responsiveness was greater with COL at 24 h (p < 0.001) and 48 h (p = 0.023) with doses ~ twofold greater required to elicit a positive response in PLA.

CONCLUSIONS: COL blunts the prolonged exercise-induced decrease in clinically relevant in vivo immune responsiveness to a novel antigen, which may be a mechanism for reduced illness reports observed in the previous studies. These findings also suggest that CHS sensitivity is highly relevant to host defence.

Medienart:

E-Artikel

Erscheinungsjahr:

2019

Erschienen:

2019

Enthalten in:

Zur Gesamtaufnahme - volume:58

Enthalten in:

European journal of nutrition - 58(2019), 1 vom: 22. Feb., Seite 335-344

Sprache:

Englisch

Beteiligte Personen:

Jones, A W [VerfasserIn]
March, D S [VerfasserIn]
Thatcher, R [VerfasserIn]
Diment, B [VerfasserIn]
Walsh, N P [VerfasserIn]
Davison, Glen [VerfasserIn]

Links:

Volltext

Themen:

Contact hypersensitivity
Diphenylcyclopropenone
Host defence
Journal Article
Randomized Controlled Trial
Running
Whole integrated immune response

Anmerkungen:

Date Completed 05.08.2019

Date Revised 25.02.2020

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1007/s00394-017-1597-6

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM27937657X