Optimisation of platelet concentrates therapy : Composition, localisation, and duration of action
Platelet concentrates (PC) generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical results urge the need to understand the working mechanism of PC. It is generally believed that the platelet-derived bioactive factors are the active constituents, and their bioavailability in the vicinity of the lesion sites determines the treatment efficacies. Therefore, the composition, localisation, and duration of the action of PC would be key determinants. In this review, we discuss how different preparations and delivery methods of PC would affect the treatment outcomes with respect to clinical evidence about PC therapy for osteoarthritis, tendinopathies, rotator cuff tears, anterior cruciate ligament injuries, and bone fractures. This review can be used as a quick guide for the use of PC therapy and provide insights for the further optimisation of the therapy in the near future.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
Asia-Pacific journal of sports medicine, arthroscopy, rehabilitation and technology - 7(2017) vom: 20. Jan., Seite 27-36 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yung, Yuk-Lin [VerfasserIn] |
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| Links: |
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| Themen: |
Composition |
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| Anmerkungen: |
Date Revised 27.03.2024 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1016/j.asmart.2016.11.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM279280815 |
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| 520 | |a Platelet concentrates (PC) generally refers to a group of products that are prepared from autologous blood intended to enhance healing activities. PC therapy is now very popular in treating musculoskeletal injuries; however, inconsistent clinical results urge the need to understand the working mechanism of PC. It is generally believed that the platelet-derived bioactive factors are the active constituents, and their bioavailability in the vicinity of the lesion sites determines the treatment efficacies. Therefore, the composition, localisation, and duration of the action of PC would be key determinants. In this review, we discuss how different preparations and delivery methods of PC would affect the treatment outcomes with respect to clinical evidence about PC therapy for osteoarthritis, tendinopathies, rotator cuff tears, anterior cruciate ligament injuries, and bone fractures. This review can be used as a quick guide for the use of PC therapy and provide insights for the further optimisation of the therapy in the near future | ||
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| 700 | 1 | |a Fu, Sai-Chuen |e verfasserin |4 aut | |
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| 700 | 1 | |a Qin, Ling |e verfasserin |4 aut | |
| 700 | 1 | |a Ong, Michael Tim-Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Chan, Kai-Ming |e verfasserin |4 aut | |
| 700 | 1 | |a Yung, Patrick Shu-Hang |e verfasserin |4 aut | |
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