Cafestol, a coffee diterpene, inhibits urotensin II-induced interleukin-8 expression in human umbilical vein endothelial cells
Copyright © 2017 Elsevier B.V. All rights reserved..
Cafestol, a diterpene molecule found in the berries of Coffea arabica L. (Rubiaceae), has been shown to exercise anti-angiogenic and anti-tumorigenic effects. However, cafestol's cellular mechanism has yet to be fully investigated. We previously demonstrated that urotensin II enhanced interleukin-8 secretion by endothelial cells, thereby increasing endothelial cell proliferation. Urotensin II may also participate in angiogenesis and tumor infiltration by macrophages. However, the effects of cafestol on urotensin II-induced interleukin-8 expression and cellular proliferation have not been determined. Here, we showed that pretreatment with cafestol inhibited urotensin II-stimulated endothelial cell proliferation. Further experiments demonstrated that cafestol increased translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and expression of enhanced heme oxygenase-1. Moreover, cafestol inhibited expression of urotensin II-induced interleukin-8. Cafestol's inhibitory effects on interleukin-8 expression and cellular proliferation induced by urotensin II were significantly abrogated by heme oxygenase-1 silencing, suggesting it may be involved in mediating the effects of cafestol. This study reports that cafestol inhibits urotensin II-induced interleukin-8 expression and cell proliferation via Nrf2/heme oxygenase-1-dependent mechanism in endothelial cells. These findings provide novel insight into the signaling pathways that may be important in mediating the effects of cafestol.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:820 |
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| Enthalten in: |
European journal of pharmacology - 820(2018) vom: 05. Feb., Seite 106-112 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tsai, Yi-Ting [VerfasserIn] |
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| Links: |
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| Themen: |
9047-55-6 |
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| Anmerkungen: |
Date Completed 06.08.2018 Date Revised 06.08.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejphar.2017.12.030 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM279113315 |
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| 520 | |a Cafestol, a diterpene molecule found in the berries of Coffea arabica L. (Rubiaceae), has been shown to exercise anti-angiogenic and anti-tumorigenic effects. However, cafestol's cellular mechanism has yet to be fully investigated. We previously demonstrated that urotensin II enhanced interleukin-8 secretion by endothelial cells, thereby increasing endothelial cell proliferation. Urotensin II may also participate in angiogenesis and tumor infiltration by macrophages. However, the effects of cafestol on urotensin II-induced interleukin-8 expression and cellular proliferation have not been determined. Here, we showed that pretreatment with cafestol inhibited urotensin II-stimulated endothelial cell proliferation. Further experiments demonstrated that cafestol increased translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and expression of enhanced heme oxygenase-1. Moreover, cafestol inhibited expression of urotensin II-induced interleukin-8. Cafestol's inhibitory effects on interleukin-8 expression and cellular proliferation induced by urotensin II were significantly abrogated by heme oxygenase-1 silencing, suggesting it may be involved in mediating the effects of cafestol. This study reports that cafestol inhibits urotensin II-induced interleukin-8 expression and cell proliferation via Nrf2/heme oxygenase-1-dependent mechanism in endothelial cells. These findings provide novel insight into the signaling pathways that may be important in mediating the effects of cafestol | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cafestol | |
| 650 | 4 | |a Endothelial cells | |
| 650 | 4 | |a Heme oxygenase-1 | |
| 650 | 4 | |a Nuclear factor erythroid 2-related factor 2 | |
| 650 | 4 | |a Urotensin II, interleukin-8 | |
| 650 | 7 | |a Diterpenes |2 NLM | |
| 650 | 7 | |a Interleukin-8 |2 NLM | |
| 650 | 7 | |a Urotensins |2 NLM | |
| 650 | 7 | |a urotensin II |2 NLM | |
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| 650 | 7 | |a cafestol |2 NLM | |
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| 700 | 1 | |a Sung, Li-Chin |e verfasserin |4 aut | |
| 700 | 1 | |a Haw, Wen-Ray |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Chun-Chao |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Shu-Fu |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Ju-Chi |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Tzu-Hurng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Po-Yuan |e verfasserin |4 aut | |
| 700 | 1 | |a Loh, Shih-Hurng |e verfasserin |4 aut | |
| 700 | 1 | |a Tsai, Chien-Sung |e verfasserin |4 aut | |
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