In vitro transdermal permeation and penetration properties for transfersomes of brucine
Copyright© by the Chinese Pharmaceutical Association..
To prepare the liposomes and transfersomes of brucine, characterize their pharmaceutical properties, and compare their in vitro transdermal permeation properties. The liposomes and transfersomes of brucine were prepared by ammonium sulfate gradient method to investigate their pharmaceutical properties such as the particle size, encapsulation efficiency and deformation. The transdermal permeation properties in vitro of liposome and transfersomes from different prescriptions were compared by using modified Franz-diffustion cells with rat skin as the transdermal barrier. The results showed that the particle size of liposomes and transfersomes for brucine ranged from 100 nm to 150 nm, with even distribution for particle size. As compared with the soybean phosphatidylcholine (SPC) transfersomes, the encapsulation efficiency of complex phospholipid transfersomes was significantly improved. The deformation index of complex phospholipid transfersomes in brucine was 2.09 times and 1.76 times as much as SPC liposomes and SPC transfersomes respectively. The steady state flux of complex phospholipid transfersomes was 3.43 times and 1.41 times as much as SPC liposomes and SPC transfersomes. The steady state flux of the physical mixture of brucine and blank complex phospholipid transfersomes was 2.20 times as much as brucine solution. The concentration of complex phospholipid had effect on transdermal permeation of blank transfersomes. In conclusion, as compared with liposomes, the permeation behavior of transfersomes was significantly improved; complex phospholipid technology can improve the membrane phase behavior of transfersomes, and further improve the deformation index and transdermal flux of transfersomes; in addition, blank transfersomes have promoting effect on transdermal absorption of brucine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:41 |
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| Enthalten in: |
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica - 41(2016), 16 vom: 18. Aug., Seite 3009-3015 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Wu, Yu [VerfasserIn] |
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| Links: |
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| Themen: |
6NG17YCK6H |
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| Anmerkungen: |
Date Completed 22.05.2018 Date Revised 02.12.2018 published: Print Citation Status MEDLINE |
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| doi: |
10.4268/cjcmm20161611 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM275910075 |
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| 245 | 1 | 0 | |a In vitro transdermal permeation and penetration properties for transfersomes of brucine |
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| 500 | |a Date Completed 22.05.2018 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© by the Chinese Pharmaceutical Association. | ||
| 520 | |a To prepare the liposomes and transfersomes of brucine, characterize their pharmaceutical properties, and compare their in vitro transdermal permeation properties. The liposomes and transfersomes of brucine were prepared by ammonium sulfate gradient method to investigate their pharmaceutical properties such as the particle size, encapsulation efficiency and deformation. The transdermal permeation properties in vitro of liposome and transfersomes from different prescriptions were compared by using modified Franz-diffustion cells with rat skin as the transdermal barrier. The results showed that the particle size of liposomes and transfersomes for brucine ranged from 100 nm to 150 nm, with even distribution for particle size. As compared with the soybean phosphatidylcholine (SPC) transfersomes, the encapsulation efficiency of complex phospholipid transfersomes was significantly improved. The deformation index of complex phospholipid transfersomes in brucine was 2.09 times and 1.76 times as much as SPC liposomes and SPC transfersomes respectively. The steady state flux of complex phospholipid transfersomes was 3.43 times and 1.41 times as much as SPC liposomes and SPC transfersomes. The steady state flux of the physical mixture of brucine and blank complex phospholipid transfersomes was 2.20 times as much as brucine solution. The concentration of complex phospholipid had effect on transdermal permeation of blank transfersomes. In conclusion, as compared with liposomes, the permeation behavior of transfersomes was significantly improved; complex phospholipid technology can improve the membrane phase behavior of transfersomes, and further improve the deformation index and transdermal flux of transfersomes; in addition, blank transfersomes have promoting effect on transdermal absorption of brucine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a brucine | |
| 650 | 4 | |a complex phospholipid | |
| 650 | 4 | |a in vitro transdermal permeation | |
| 650 | 4 | |a transfersome | |
| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Liposomes |2 NLM | |
| 650 | 7 | |a brucine |2 NLM | |
| 650 | 7 | |a 6NG17YCK6H |2 NLM | |
| 650 | 7 | |a Strychnine |2 NLM | |
| 650 | 7 | |a H9Y79VD43J |2 NLM | |
| 700 | 1 | |a Chen, Jun |e verfasserin |4 aut | |
| 700 | 1 | |a Fang, Yun |e verfasserin |4 aut | |
| 700 | 1 | |a Dong, Jie |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:41 |g year:2016 |g number:16 |g day:18 |g month:08 |g pages:3009-3015 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4268/cjcmm20161611 |3 Volltext |
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