Three-dimensional mapping of brain venous oxygenation using R2* oximetry
© 2017 International Society for Magnetic Resonance in Medicine..
PURPOSE: Cerebral venous oxygenation (Yv ) is an important biomarker for brain diseases. This study aims to develop an R2*-based MR oximetry that can measure cerebral Yv in 3D.
METHODS: This technique separates blood signal from tissue by velocity-encoding phase contrast and measures the R2* of pure blood by multi-gradient-echo acquisition. The blood R2* was converted to Yv using an R2*-versus-oxygenation (Y) calibration curve, which was obtained by in vitro bovine blood experiments. Reproducibility, sensitivity, validity, and resolution dependence of the technique were evaluated.
RESULTS: In vitro R2*-Y calibration plot revealed a strong dependence of blood R2* on oxygenation, with additional dependence on hematocrit. In vivo results demonstrated that the technique can provide a 3D venous oxygenation map that depicts both large sinuses and smaller cortical veins, with venous oxygenation ranging from 57 to 72%. Intrasession coefficient of variation of the measurement was 3.0%. The technique detected an average Yv increase of 10.8% as a result of hyperoxia, which was validated by global oxygenation measurement from T2 -Relaxation-Under-Spin-Tagging (TRUST) MRI. Two spatial resolutions, one with an isotropic voxel dimension and the other with a nonisotropic dimension, were tested for full brain coverage.
CONCLUSIONS: This study demonstrated the feasibility of 3D brain oxygenation mapping without using contrast agent. Magn Reson Med 79:1304-1313, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2018 |
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| Erschienen: |
2018 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:79 |
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| Enthalten in: |
Magnetic resonance in medicine - 79(2018), 3 vom: 05. März, Seite 1304-1313 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mao, Deng [VerfasserIn] |
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| Links: |
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| Themen: |
Blood R2* |
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| Anmerkungen: |
Date Completed 26.04.2019 Date Revised 26.04.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/mrm.26763 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM272654760 |
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| 245 | 1 | 0 | |a Three-dimensional mapping of brain venous oxygenation using R2* oximetry |
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| 500 | |a Date Revised 26.04.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2017 International Society for Magnetic Resonance in Medicine. | ||
| 520 | |a PURPOSE: Cerebral venous oxygenation (Yv ) is an important biomarker for brain diseases. This study aims to develop an R2*-based MR oximetry that can measure cerebral Yv in 3D | ||
| 520 | |a METHODS: This technique separates blood signal from tissue by velocity-encoding phase contrast and measures the R2* of pure blood by multi-gradient-echo acquisition. The blood R2* was converted to Yv using an R2*-versus-oxygenation (Y) calibration curve, which was obtained by in vitro bovine blood experiments. Reproducibility, sensitivity, validity, and resolution dependence of the technique were evaluated | ||
| 520 | |a RESULTS: In vitro R2*-Y calibration plot revealed a strong dependence of blood R2* on oxygenation, with additional dependence on hematocrit. In vivo results demonstrated that the technique can provide a 3D venous oxygenation map that depicts both large sinuses and smaller cortical veins, with venous oxygenation ranging from 57 to 72%. Intrasession coefficient of variation of the measurement was 3.0%. The technique detected an average Yv increase of 10.8% as a result of hyperoxia, which was validated by global oxygenation measurement from T2 -Relaxation-Under-Spin-Tagging (TRUST) MRI. Two spatial resolutions, one with an isotropic voxel dimension and the other with a nonisotropic dimension, were tested for full brain coverage | ||
| 520 | |a CONCLUSIONS: This study demonstrated the feasibility of 3D brain oxygenation mapping without using contrast agent. Magn Reson Med 79:1304-1313, 2018. © 2017 International Society for Magnetic Resonance in Medicine | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a MR oximetry | |
| 650 | 4 | |a blood R2* | |
| 650 | 4 | |a blood oxygenation | |
| 650 | 4 | |a hyperoxia | |
| 650 | 4 | |a phase contrast | |
| 650 | 4 | |a venogram | |
| 700 | 1 | |a Li, Yang |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Peiying |e verfasserin |4 aut | |
| 700 | 1 | |a Peng, Shin-Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Pillai, Jay J |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Hanzhang |e verfasserin |4 aut | |
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