Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation
Copyright © 2016 Elsevier B.V. All rights reserved..
Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential for the development and maintenance of malignancy. Both proteins function by targeting critical pathways that are essential for maintaining cellular homeostasis. As a consequence of these activities, this produces an environment that is favourable for the normal viral life cycle, but when perturbed, can result in the initiation of changes to the host cell, which ultimately results in the development of a malignancy. In this review we discuss the role of these different functions of the viral oncoproteins during the viral life cycle and carcinogenesis, with an emphasis on how induction of DNA damage by the viral oncoproteins, in conjunction with the stem like nature of the target cells, can ultimately result in the development of cancer.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2017 |
---|---|
Erschienen: |
2017 |
Enthalten in: |
Zur Gesamtaufnahme - volume:772 |
---|---|
Enthalten in: |
Mutation research. Reviews in mutation research - 772(2017) vom: 10. Apr., Seite 23-35 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Mittal, Suruchi [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 25.08.2017 Date Revised 30.03.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1016/j.mrrev.2016.08.001 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM272109053 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLM272109053 | ||
003 | DE-627 | ||
005 | 20231226193916.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2017 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1016/j.mrrev.2016.08.001 |2 doi | |
028 | 5 | 2 | |a pubmed24n0907.xml |
035 | |a (DE-627)NLM272109053 | ||
035 | |a (NLM)28528687 | ||
035 | |a (PII)S1383-5742(16)30082-5 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Mittal, Suruchi |e verfasserin |4 aut | |
245 | 1 | 0 | |a Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation |
264 | 1 | |c 2017 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 25.08.2017 | ||
500 | |a Date Revised 30.03.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2016 Elsevier B.V. All rights reserved. | ||
520 | |a Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential for the development and maintenance of malignancy. Both proteins function by targeting critical pathways that are essential for maintaining cellular homeostasis. As a consequence of these activities, this produces an environment that is favourable for the normal viral life cycle, but when perturbed, can result in the initiation of changes to the host cell, which ultimately results in the development of a malignancy. In this review we discuss the role of these different functions of the viral oncoproteins during the viral life cycle and carcinogenesis, with an emphasis on how induction of DNA damage by the viral oncoproteins, in conjunction with the stem like nature of the target cells, can ultimately result in the development of cancer | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Review | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Cervical Cancer | |
650 | 4 | |a Cervical Cancer Stem Cells | |
650 | 4 | |a HPV | |
650 | 4 | |a HPV E6 | |
650 | 4 | |a HPV E7 | |
650 | 7 | |a DNA-Binding Proteins |2 NLM | |
650 | 7 | |a E6 protein, Human papillomavirus type 16 |2 NLM | |
650 | 7 | |a E6 protein, Human papillomavirus type 18 |2 NLM | |
650 | 7 | |a Oncogene Proteins, Viral |2 NLM | |
650 | 7 | |a Papillomavirus E7 Proteins |2 NLM | |
650 | 7 | |a Repressor Proteins |2 NLM | |
700 | 1 | |a Banks, Lawrence |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Mutation research. Reviews in mutation research |d 2012 |g 772(2017) vom: 10. Apr., Seite 23-35 |w (DE-627)NLM216126231 |x 1388-2139 |7 nnns |
773 | 1 | 8 | |g volume:772 |g year:2017 |g day:10 |g month:04 |g pages:23-35 |
856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.mrrev.2016.08.001 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 772 |j 2017 |b 10 |c 04 |h 23-35 |