Molecular mechanisms underlying human papillomavirus E6 and E7 oncoprotein-induced cell transformation

Copyright © 2016 Elsevier B.V. All rights reserved..

Human papillomaviruses (HPVs) are the causative agents of 5% of all human cancers, with cervical cancer being the most important. Two viral oncoproteins, E6 and E7, are essential for the development and maintenance of malignancy. Both proteins function by targeting critical pathways that are essential for maintaining cellular homeostasis. As a consequence of these activities, this produces an environment that is favourable for the normal viral life cycle, but when perturbed, can result in the initiation of changes to the host cell, which ultimately results in the development of a malignancy. In this review we discuss the role of these different functions of the viral oncoproteins during the viral life cycle and carcinogenesis, with an emphasis on how induction of DNA damage by the viral oncoproteins, in conjunction with the stem like nature of the target cells, can ultimately result in the development of cancer.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:772

Enthalten in:

Mutation research. Reviews in mutation research - 772(2017) vom: 10. Apr., Seite 23-35

Sprache:

Englisch

Beteiligte Personen:

Mittal, Suruchi [VerfasserIn]
Banks, Lawrence [VerfasserIn]

Links:

Volltext

Themen:

Cervical Cancer
Cervical Cancer Stem Cells
DNA-Binding Proteins
E6 protein, Human papillomavirus type 16
E6 protein, Human papillomavirus type 18
HPV
HPV E6
HPV E7
Journal Article
Oncogene Proteins, Viral
Papillomavirus E7 Proteins
Repressor Proteins
Research Support, Non-U.S. Gov't
Review

Anmerkungen:

Date Completed 25.08.2017

Date Revised 30.03.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.mrrev.2016.08.001

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM272109053