Do prophylactic antibiotics in gynecologic surgery prevent postoperative inflammatory complications? A systematic review
PURPOSE: The aim of this study was to systematically review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations. The study was carried out as a systematic review.
METHODS: Only randomised controlled trials of women undergoing gynaecological surgery were included. The Medline and the Cochrane library databases were searched from 1966 to 2016. The trials must have investigated an antibiotic intervention to prevent an inflammatory complication after gynaecological surgery. Trials were excluded if they were not randomised, uncontrolled or included obstetrical surgery.
RESULTS: Prophylactic antibiotics prevent inflammatory complications after gynaecological surgery. Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina. Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin. No benefit has been shown for the combination of antibiotics as prophylaxis. No difference has been shown between the long-term and short-term use of antibiotics. There is no need for the primary use of an anaerobic antibacterial agent.
CONCLUSION: Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:295 |
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| Enthalten in: |
Archives of gynecology and obstetrics - 295(2017), 6 vom: 03. Juni, Seite 1383-1391 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boesch, Cedric Emanuel [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Bacterial Agents |
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| Anmerkungen: |
Date Completed 03.11.2017 Date Revised 02.12.2018 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00404-017-4382-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM271518227 |
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| 100 | 1 | |a Boesch, Cedric Emanuel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Do prophylactic antibiotics in gynecologic surgery prevent postoperative inflammatory complications? A systematic review |
| 264 | 1 | |c 2017 | |
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| 500 | |a Date Completed 03.11.2017 | ||
| 500 | |a Date Revised 02.12.2018 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a PURPOSE: The aim of this study was to systematically review the literature on antibiotic prophylaxis in gynaecologic surgeries to prevent inflammatory complications after gynaecological operations. The study was carried out as a systematic review | ||
| 520 | |a METHODS: Only randomised controlled trials of women undergoing gynaecological surgery were included. The Medline and the Cochrane library databases were searched from 1966 to 2016. The trials must have investigated an antibiotic intervention to prevent an inflammatory complication after gynaecological surgery. Trials were excluded if they were not randomised, uncontrolled or included obstetrical surgery | ||
| 520 | |a RESULTS: Prophylactic antibiotics prevent inflammatory complications after gynaecological surgery. Prophylactic antibiotics are more effective in surgery requiring access to the peritoneal cavity or the vagina. Cefotetan appears to be more capable in preventing the overall inflammatory complication rate than cefoxitin or cefazolin. No benefit has been shown for the combination of antibiotics as prophylaxis. No difference has been shown between the long-term and short-term use of antibiotics. There is no need for the primary use of an anaerobic antibacterial agent | ||
| 520 | |a CONCLUSION: Antibiotics help to prevent postoperative inflammatory complications after major gynecologic surgeries | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a Antibiotic | |
| 650 | 4 | |a Gynecology | |
| 650 | 4 | |a Prophylaxis | |
| 650 | 4 | |a Surgery | |
| 650 | 4 | |a Systematic review | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Pronk, Roderick Franziskus |e verfasserin |4 aut | |
| 700 | 1 | |a Medved, Fabian |e verfasserin |4 aut | |
| 700 | 1 | |a Hentschel, Pascal |e verfasserin |4 aut | |
| 700 | 1 | |a Schaller, Hans-Eberhard |e verfasserin |4 aut | |
| 700 | 1 | |a Umek, Wolfgang |e verfasserin |4 aut | |
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