Abnormal implantation after fresh and frozen in vitro fertilization cycles
Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: To determine whether fresh embryo transfers are at a higher risk of abnormal implantation compared with frozen embryo transfers while accounting for the embryo stage at transfer.
DESIGN: Retrospective cohort study.
SETTING: Not applicable.
PATIENT(S): We used data from the Society for Assisted Reproductive Technologies to identify all fresh and frozen autologous IVF cycles from 2004-2013 resulting in a positive pregnancy test. The cycles were parameterized into a four-level predictor of [1] fresh blastocyst transfer, [2] fresh non-blastocyst transfer, [3] frozen blastocyst transfer, and [4] frozen non-blastocyst transfer.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): We examined a composite outcome of abnormal implantation, defined as biochemical pregnancy, ectopic/heterotopic pregnancy, and first-trimester pregnancy loss. Regression modeling was performed with repeated measures multivariable logistic regression, adjusted for age, parity, number of embryos transferred, infertility diagnosis, and calendar year of treatment.
RESULT(S): Of 509,938 cycles analyzed, 31.8% resulted in abnormal implantation. Compared with a fresh blastocyst transfer, a fresh non-blastocyst transfer had a 22% increase risk of abnormal implantation, a frozen blastocyst transfer had a 36% increase risk, and a frozen non-blastocyst transfer had a 57% increase risk. When individual outcomes were analyzed, fresh embryo transfers had a lower risk of biochemical pregnancy and pregnancy loss but a higher risk for ectopic/heterotopic pregnancy.
CONCLUSION(S): Fresh blastocyst transfers had the lowest overall risk of abnormal implantation but a higher risk of ectopic/heterotopic pregnancy. Although embryo cryopreservation is indicated in certain treatment cycles, elective embryo cryopreservation may not be the optimal strategy to adopt for all cycles.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2017 |
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| Erschienen: |
2017 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:107 |
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| Enthalten in: |
Fertility and sterility - 107(2017), 5 vom: 15. Mai, Seite 1153-1158 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Erica T [VerfasserIn] |
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| Links: |
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| Themen: |
Abnormal implantation |
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| Anmerkungen: |
Date Completed 18.08.2017 Date Revised 27.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.fertnstert.2017.03.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a Date Completed 18.08.2017 | ||
| 500 | |a Date Revised 27.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2017 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To determine whether fresh embryo transfers are at a higher risk of abnormal implantation compared with frozen embryo transfers while accounting for the embryo stage at transfer | ||
| 520 | |a DESIGN: Retrospective cohort study | ||
| 520 | |a SETTING: Not applicable | ||
| 520 | |a PATIENT(S): We used data from the Society for Assisted Reproductive Technologies to identify all fresh and frozen autologous IVF cycles from 2004-2013 resulting in a positive pregnancy test. The cycles were parameterized into a four-level predictor of [1] fresh blastocyst transfer, [2] fresh non-blastocyst transfer, [3] frozen blastocyst transfer, and [4] frozen non-blastocyst transfer | ||
| 520 | |a INTERVENTION(S): None | ||
| 520 | |a MAIN OUTCOME MEASURE(S): We examined a composite outcome of abnormal implantation, defined as biochemical pregnancy, ectopic/heterotopic pregnancy, and first-trimester pregnancy loss. Regression modeling was performed with repeated measures multivariable logistic regression, adjusted for age, parity, number of embryos transferred, infertility diagnosis, and calendar year of treatment | ||
| 520 | |a RESULT(S): Of 509,938 cycles analyzed, 31.8% resulted in abnormal implantation. Compared with a fresh blastocyst transfer, a fresh non-blastocyst transfer had a 22% increase risk of abnormal implantation, a frozen blastocyst transfer had a 36% increase risk, and a frozen non-blastocyst transfer had a 57% increase risk. When individual outcomes were analyzed, fresh embryo transfers had a lower risk of biochemical pregnancy and pregnancy loss but a higher risk for ectopic/heterotopic pregnancy | ||
| 520 | |a CONCLUSION(S): Fresh blastocyst transfers had the lowest overall risk of abnormal implantation but a higher risk of ectopic/heterotopic pregnancy. Although embryo cryopreservation is indicated in certain treatment cycles, elective embryo cryopreservation may not be the optimal strategy to adopt for all cycles | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Abnormal implantation | |
| 650 | 4 | |a embryo cryopreservation | |
| 650 | 4 | |a in vitro fertilization | |
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| 700 | 1 | |a Bresee, Catherine |e verfasserin |4 aut | |
| 700 | 1 | |a Greene, Naomi |e verfasserin |4 aut | |
| 700 | 1 | |a Alexander, Carolyn |e verfasserin |4 aut | |
| 700 | 1 | |a Pisarska, Margareta D |e verfasserin |4 aut | |
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