Facile Synthesis and Chiral Separation of Chiral Mesoporous Silica Microspheres

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Mesoporous silica microspheres were synthesized by an acid-catalyzed sol-gel method using tetraethoxysilane (TEOS) as a precursor. The hydrochloric acid was used as a catalyzer to induce the hydrolysis of TEOS, while the cyclohexane acted as a stabilizer of the sol. The addition of polyethylene glycol can introduce the uniform mesoporous structure into the microspheres by phase separation. The as-prepared mesoporous silica microspheres possess a narrow particle size distribution, a mesopore size of 5.0 nm and a Brunauer-Emmett-Teller specific surface area as high as 230 m2·g-1. The resultant silica microspheres were used for packing chiral high-performance liquid chromatography (HPLC) columns, after activated by hydrochloric acid and modified by amylose-tris(3,5-dimethylphenylcarbamate), respectively. The flurbiprofen axetil as a typical chiral drug with two stereocenters can be successfully separated by the as-obtained chiral HPLC columns using different mobile phases.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:55

Enthalten in:

Journal of chromatographic science - 55(2017), 7 vom: 01. Aug., Seite 736-741

Sprache:

Englisch

Beteiligte Personen:

Wang, Rui [VerfasserIn]
Yang, Hui [VerfasserIn]
Xue, Kunpeng [VerfasserIn]
Zhao, Yuexing [VerfasserIn]
Guo, Xingzhong [VerfasserIn]

Links:

Volltext

Themen:

Journal Article

Anmerkungen:

Date Completed 29.01.2018

Date Revised 29.01.2018

published: Print

Citation Status PubMed-not-MEDLINE

doi:

10.1093/chromsci/bmx028

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM270754407