Sustained Drug Release by Thermoresponsive Sol-Gel Hybrid Hydrogels of Poly(N-Isopropylacrylamide-co-3-(Trimethoxysilyl)Propyl Methacrylate) Copolymers

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim..

Poly(N-isopropylacrylamide-co-3-(trimethoxysilyl)propyl methacrylate), P(NIPAAm-co-TMSPMA), copolymers with relatively high TMSPMA contents without insoluble fraction are successfully synthesized. Subsequent sol-gel reactions in both the absence and presence of tetraethyl orthosilicate lead to gels with high gel fractions. The resulting gels undergo gel collapse at 28.6-28.7 °C, i.e., below that of poly(N-isopropylacrylamide) homopolymer of 34.3 °C. Unexpectedly, the theophylline-loaded hybrid gels release the drug not only below but also above the gel collapse temperature (GCT) with considerable rates and released amounts of drug. Surprisingly, evaluation of the sustained release profiles by the Korsmeyer-Peppas equation indicates that the release occurs by Fickian diffusion above GCT, which can be attributed to the lack of significant drug-polymer interaction at such temperatures. These results can be widely applied for the design and utilization of TMSPMA-based sol-gel polymer hybrids with desired release profiles of solutes below and above GCT for a variety of applications.

Medienart:

E-Artikel

Erscheinungsjahr:

2017

Erschienen:

2017

Enthalten in:

Zur Gesamtaufnahme - volume:38

Enthalten in:

Macromolecular rapid communications - 38(2017), 6 vom: 22. März

Sprache:

Englisch

Beteiligte Personen:

Osváth, Zsófia [VerfasserIn]
Tóth, Tamás [VerfasserIn]
Iván, Béla [VerfasserIn]

Links:

Volltext

Themen:

3-(trimethoxysilyl)propyl methacrylate, copolymers
Acrylic Resins
Hybrid gels
Hydrogels
Journal Article
Lower critical solution temperature (LCST)-type copolymers and gels
Poly(N-isopropylacrylamide)
Poly(N-isopropylacrylamide-co-3-(trimethoxysilyl)propyl methacrylate)
Temperature- and composition-dependent sustained drug release

Anmerkungen:

Date Completed 17.04.2017

Date Revised 17.04.2017

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/marc.201600724

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM268703612