Effect of thyroid peroxidase antibodies on thyroid-stimulating hormone reference limits in a primarily Latina population
The aim of the paper is to determine the prevalence of thyroid peroxidase antibodies (TPOAb) and assess its effect on the thyroid-stimulating hormone (TSH) reference range during pregnancy in a primarily Latina population. Serum samples were collected from healthy pregnant women and non-pregnant controls. TSH reference ranges were calculated when TPOAb-positive patients were either included or excluded. A total of 134 pregnant women and 107 non-pregnant controls were recruited. Positive TPOAb titres were found in 23 (17.2%) of the 134 pregnant women, and in 14 (13.1%) of the 107 non-pregnant controls. When the TPOAb-positive women were included in the TSH analysis, the upper reference limit using two different methods was consistently higher: 0-2.2 fold in the non-pregnant women, 2.01-2.78 fold in the first trimester, 3.18-4.7 fold in the second and 1.05-1.42 fold in the third. The lower TSH reference limit was not affected by the inclusion of TPOAb-positive subjects. In conclusion, inclusion of TPOAb-positive patients results in higher upper reference limits during pregnancy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:2 |
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| Enthalten in: |
Obstetric medicine - 2(2009), 4 vom: 01. Dez., Seite 154-6 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lee, Richard H [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 31.08.2016 Date Revised 29.09.2020 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1258/om.2009.090039 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM263913295 |
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| 500 | |a Date Revised 29.09.2020 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a The aim of the paper is to determine the prevalence of thyroid peroxidase antibodies (TPOAb) and assess its effect on the thyroid-stimulating hormone (TSH) reference range during pregnancy in a primarily Latina population. Serum samples were collected from healthy pregnant women and non-pregnant controls. TSH reference ranges were calculated when TPOAb-positive patients were either included or excluded. A total of 134 pregnant women and 107 non-pregnant controls were recruited. Positive TPOAb titres were found in 23 (17.2%) of the 134 pregnant women, and in 14 (13.1%) of the 107 non-pregnant controls. When the TPOAb-positive women were included in the TSH analysis, the upper reference limit using two different methods was consistently higher: 0-2.2 fold in the non-pregnant women, 2.01-2.78 fold in the first trimester, 3.18-4.7 fold in the second and 1.05-1.42 fold in the third. The lower TSH reference limit was not affected by the inclusion of TPOAb-positive subjects. In conclusion, inclusion of TPOAb-positive patients results in higher upper reference limits during pregnancy | ||
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| 700 | 1 | |a Spencer, Carole A |e verfasserin |4 aut | |
| 700 | 1 | |a Montoro, Martin N |e verfasserin |4 aut | |
| 700 | 1 | |a Aghajanian, Paola |e verfasserin |4 aut | |
| 700 | 1 | |a Goodwin, T Murphy |e verfasserin |4 aut | |
| 700 | 1 | |a Miller, Erin A |e verfasserin |4 aut | |
| 700 | 1 | |a Petrovic, Ivana |e verfasserin |4 aut | |
| 700 | 1 | |a Braverman, Lewis E |e verfasserin |4 aut | |
| 700 | 1 | |a Mestman, Jorge H |e verfasserin |4 aut | |
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