Changes in the Immune Components of Preterm Human Milk and Associations With Maternal and Infant Characteristics
Copyright © 2016 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: To describe difference in cytokines, chemokines, and growth factors (CCGFs) and secretory immunoglobulin A (sIgA) in the breast milk of mothers who gave birth preterm and maternal or infant characteristics related to these immune components.
DESIGN: A prospective, repeated-measures, one-group design.
SETTING: Data were collected at an 82-bed NICU in West Central Florida.
PARTICIPANTS: Seventy-six very-low-birth-weight infants weighing less than 1,500 g and their mothers.
METHODS: Daily aliquots of breast milk from mothers of preterm infants were collected from the daily infants' feedings and pooled at the end of each week, and CCGFs and sIgA were measured weekly with MagPix multiplexing (Luminex, Austin, TX) and enzyme-linked immunosorbent assay.
RESULTS: The CCGFs showed high individual variability, but the levels of most CCGFs and sIgA fell over time. Immune variables were generally greater in milk from mothers of infants smaller than 1,000 g. The breast milk of mothers of male preterm infants had significantly greater sIgA than the breast milk of mothers of female preterm infants. We found relationships between age, body mass index, parity, sIgA, and some of the CCGFs in the breast milk of women who gave birth preterm.
CONCLUSION: Immune molecules declined in concentration over time in the breast milk of mothers who give birth preterm during the NICU stay, and maternal and infant factors appeared to play some role in the levels of these immune molecules. Further exploration of this relationship is warranted.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:45 |
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| Enthalten in: |
Journal of obstetric, gynecologic, and neonatal nursing : JOGNN - 45(2016), 5 vom: 09. Sept., Seite 639-48 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Groer, Maureen [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 06.04.2018 Date Revised 09.01.2019 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jogn.2016.04.009 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM262988178 |
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| 245 | 1 | 0 | |a Changes in the Immune Components of Preterm Human Milk and Associations With Maternal and Infant Characteristics |
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| 500 | |a Date Completed 06.04.2018 | ||
| 500 | |a Date Revised 09.01.2019 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 AWHONN, the Association of Women’s Health, Obstetric and Neonatal Nurses. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To describe difference in cytokines, chemokines, and growth factors (CCGFs) and secretory immunoglobulin A (sIgA) in the breast milk of mothers who gave birth preterm and maternal or infant characteristics related to these immune components | ||
| 520 | |a DESIGN: A prospective, repeated-measures, one-group design | ||
| 520 | |a SETTING: Data were collected at an 82-bed NICU in West Central Florida | ||
| 520 | |a PARTICIPANTS: Seventy-six very-low-birth-weight infants weighing less than 1,500 g and their mothers | ||
| 520 | |a METHODS: Daily aliquots of breast milk from mothers of preterm infants were collected from the daily infants' feedings and pooled at the end of each week, and CCGFs and sIgA were measured weekly with MagPix multiplexing (Luminex, Austin, TX) and enzyme-linked immunosorbent assay | ||
| 520 | |a RESULTS: The CCGFs showed high individual variability, but the levels of most CCGFs and sIgA fell over time. Immune variables were generally greater in milk from mothers of infants smaller than 1,000 g. The breast milk of mothers of male preterm infants had significantly greater sIgA than the breast milk of mothers of female preterm infants. We found relationships between age, body mass index, parity, sIgA, and some of the CCGFs in the breast milk of women who gave birth preterm | ||
| 520 | |a CONCLUSION: Immune molecules declined in concentration over time in the breast milk of mothers who give birth preterm during the NICU stay, and maternal and infant factors appeared to play some role in the levels of these immune molecules. Further exploration of this relationship is warranted | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a human milk | |
| 650 | 4 | |a immunity | |
| 650 | 4 | |a preterm infants | |
| 700 | 1 | |a Ashmeade, Terri |e verfasserin |4 aut | |
| 700 | 1 | |a Duffy, Allyson |e verfasserin |4 aut | |
| 700 | 1 | |a Morse, Shannon |e verfasserin |4 aut | |
| 700 | 1 | |a Zaritt, Judy |e verfasserin |4 aut | |
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