The peak of blood lactate during the first 24h predicts mortality in acute coronary syndrome patients under extracorporeal membrane oxygenation
Copyright © 2016 Elsevier Ireland Ltd. All rights reserved..
BACKGROUND: Parameters allowing for outcome discrimination of extracorporeal membrane oxygenation (ECMO) therapy in acute coronary syndromes (ACS) complicated by refractory cardiogenic shock (CS) and/or cardio-respiratory arrest (CA) remain elusive. We aimed at evaluating the potential prognostic roles of blood and procedural parameters associated with 30-day mortality following ECMO.
METHODS AND RESULTS: A group of 29 patients with ACS complicated by CS and/or CA, who underwent ECMO at a single center, was retrospectively analyzed. Eighteen patients (62%) died at 30-day follow up. "Survivors" and "non-survivors" had similar demographics, clinical and biochemical characteristics at admission, except for blood lactate peak in the first 24h that was increased in non-survivors. Procedural characteristics of percutaneous coronary intervention (PCI) and ECMO were comparable in either group. The peak of blood lactate concentration predicted 30-day mortality independently of age, sex and ECMO duration. The cutoff value, determined by receiver operating characteristic (ROC) curve analysis, was found at 11mmol/l.
CONCLUSIONS: The peak of serum lactate under ECMO in the first 24h predicted 30-day mortality in patients with ACS complicated with CS and CA.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:221 |
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| Enthalten in: |
International journal of cardiology - 221(2016) vom: 15. Okt., Seite 741-5 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rigamonti, Fabio [VerfasserIn] |
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| Links: |
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| Themen: |
33X04XA5AT |
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| Anmerkungen: |
Date Completed 05.09.2017 Date Revised 06.09.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2016.07.065 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM262525216 |
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| 100 | 1 | |a Rigamonti, Fabio |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The peak of blood lactate during the first 24h predicts mortality in acute coronary syndrome patients under extracorporeal membrane oxygenation |
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| 500 | |a Date Revised 06.09.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 Elsevier Ireland Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Parameters allowing for outcome discrimination of extracorporeal membrane oxygenation (ECMO) therapy in acute coronary syndromes (ACS) complicated by refractory cardiogenic shock (CS) and/or cardio-respiratory arrest (CA) remain elusive. We aimed at evaluating the potential prognostic roles of blood and procedural parameters associated with 30-day mortality following ECMO | ||
| 520 | |a METHODS AND RESULTS: A group of 29 patients with ACS complicated by CS and/or CA, who underwent ECMO at a single center, was retrospectively analyzed. Eighteen patients (62%) died at 30-day follow up. "Survivors" and "non-survivors" had similar demographics, clinical and biochemical characteristics at admission, except for blood lactate peak in the first 24h that was increased in non-survivors. Procedural characteristics of percutaneous coronary intervention (PCI) and ECMO were comparable in either group. The peak of blood lactate concentration predicted 30-day mortality independently of age, sex and ECMO duration. The cutoff value, determined by receiver operating characteristic (ROC) curve analysis, was found at 11mmol/l | ||
| 520 | |a CONCLUSIONS: The peak of serum lactate under ECMO in the first 24h predicted 30-day mortality in patients with ACS complicated with CS and CA | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acute coronary syndrome | |
| 650 | 4 | |a Cardiogenic shock | |
| 650 | 4 | |a Extracorporeal cardiopulmonary resuscitation | |
| 650 | 4 | |a Extracorporeal membrane oxygenation | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Lactic Acid |2 NLM | |
| 650 | 7 | |a 33X04XA5AT |2 NLM | |
| 700 | 1 | |a Montecucco, Fabrizio |e verfasserin |4 aut | |
| 700 | 1 | |a Boroli, Filippo |e verfasserin |4 aut | |
| 700 | 1 | |a Rey, Florian |e verfasserin |4 aut | |
| 700 | 1 | |a Gencer, Baris |e verfasserin |4 aut | |
| 700 | 1 | |a Cikirikcioglu, Mustafa |e verfasserin |4 aut | |
| 700 | 1 | |a Reverdin, Stéphane |e verfasserin |4 aut | |
| 700 | 1 | |a Carbone, Federico |e verfasserin |4 aut | |
| 700 | 1 | |a Noble, Stephane |e verfasserin |4 aut | |
| 700 | 1 | |a Roffi, Marco |e verfasserin |4 aut | |
| 700 | 1 | |a Banfi, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Giraud, Raphael |e verfasserin |4 aut | |
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