Timing of high-frequency cortical stimulation in a genetic absence model
Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved..
INTRODUCTION: Seizure control is one of the ultimate aims of epileptology: here acute and prolonged effects of closed loop high-frequency stimulation of the somatosensory cortex on the expression of spontaneously occurring spike-wave discharges (SWD) were investigated in a genetic absence model. Effects of closed loop stimulation in the experimental group were compared with a yoked control group allowing to investigate the effect of timing related to SWD occurrence, while controlling for amount and intensity of stimulation.
METHODS: WAG/Rij rats were implanted with stimulation electrodes in the deep layers of the somatosensory cortex, and recording electrodes in the cortex and thalamus. Closed-loop and yoked stimulation (1 sec trains, biphasic 0.4 msec pulses, 130 Hz) sessions lasted 24h. The stimulation sessions were preceded and followed by baseline and post stimulation 24-h recordings.
RESULTS: Closed-loop stimulation interrupted SWD and duration of SWD was shortened. Both types of stimulation resulted in a reduction in SWD number during stimulation sessions. Closed-loop stimulation also resulted in less SWD during the last eight hours of the post-stimulation recording session. Sometimes yoked stimulation induced low-frequency afterdischarges.
DISCUSSION: SWD can be aborted by closed-loop stimulation of the somatosensory cortex, and at the same time the number of SWD was reduced. It can be regarded as a relatively safe neuromodulatory technique without habituation. The reduction of SWD during yoked stimulation session might be caused by 3 Hz afterdischarges. The reduction of SWD on the stimulation and post-stimulation sessions demonstrates the critical relevance of timing for the induction of longer lasting neuromodulatory effects: it suggests that absence seizures themselves might be involved in their reoccurrence.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2016 |
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| Erschienen: |
2016 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:324 |
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| Enthalten in: |
Neuroscience - 324(2016) vom: 02. Juni, Seite 191-201 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
van Heukelum, S [VerfasserIn] |
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| Links: |
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| Themen: |
Deep brain stimulation |
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| Anmerkungen: |
Date Completed 10.01.2017 Date Revised 11.01.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.neuroscience.2016.02.070 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM258304502 |
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| 500 | |a Date Revised 11.01.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved. | ||
| 520 | |a INTRODUCTION: Seizure control is one of the ultimate aims of epileptology: here acute and prolonged effects of closed loop high-frequency stimulation of the somatosensory cortex on the expression of spontaneously occurring spike-wave discharges (SWD) were investigated in a genetic absence model. Effects of closed loop stimulation in the experimental group were compared with a yoked control group allowing to investigate the effect of timing related to SWD occurrence, while controlling for amount and intensity of stimulation | ||
| 520 | |a METHODS: WAG/Rij rats were implanted with stimulation electrodes in the deep layers of the somatosensory cortex, and recording electrodes in the cortex and thalamus. Closed-loop and yoked stimulation (1 sec trains, biphasic 0.4 msec pulses, 130 Hz) sessions lasted 24h. The stimulation sessions were preceded and followed by baseline and post stimulation 24-h recordings | ||
| 520 | |a RESULTS: Closed-loop stimulation interrupted SWD and duration of SWD was shortened. Both types of stimulation resulted in a reduction in SWD number during stimulation sessions. Closed-loop stimulation also resulted in less SWD during the last eight hours of the post-stimulation recording session. Sometimes yoked stimulation induced low-frequency afterdischarges | ||
| 520 | |a DISCUSSION: SWD can be aborted by closed-loop stimulation of the somatosensory cortex, and at the same time the number of SWD was reduced. It can be regarded as a relatively safe neuromodulatory technique without habituation. The reduction of SWD during yoked stimulation session might be caused by 3 Hz afterdischarges. The reduction of SWD on the stimulation and post-stimulation sessions demonstrates the critical relevance of timing for the induction of longer lasting neuromodulatory effects: it suggests that absence seizures themselves might be involved in their reoccurrence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a WAG/Rij rats | |
| 650 | 4 | |a deep brain stimulation | |
| 650 | 4 | |a neuroplasticity | |
| 650 | 4 | |a somatosensory cortex | |
| 650 | 4 | |a spike-wave discharges | |
| 650 | 4 | |a yoked control stimulation | |
| 700 | 1 | |a Kelderhuis, J |e verfasserin |4 aut | |
| 700 | 1 | |a Janssen, P |e verfasserin |4 aut | |
| 700 | 1 | |a van Luijtelaar, G |e verfasserin |4 aut | |
| 700 | 1 | |a Lüttjohann, A |e verfasserin |4 aut | |
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