Cyclophosphamide plus granulocyte-colony stimulating factor for hematopoietic stem cell mobilization in patients with multiple myeloma

© 2015 Wiley Periodicals, Inc..

We retrospectively reviewed the results of cyclophosphamide (3 g/m(2) ), doxorubicin and dexamethasone plus granulocyte-colony stimulating factor (G-CSF) (ID-CY/DOX group), low-dose cyclophosphamide (2 g/m(2) ) plus G-CSF (LD-CY group) and G-CSF alone (G-CSF group) for stem cell mobilization in patients with multiple myeloma. A total of 89 patients with 93 mobilizations were included. Apheresis was started when total white blood cell (WBC) count >10 × 10(9) /L for ID-CY/DOX and LD-CY groups and after eight doses of G-CSF (5 μg/kg twice daily) for G-CSF group. For five mobilizations in ID-CY/DOX group, the rate of successful mobilization (≥4.0 × 10(6) /kg CD34+ cells) was 80%. For 78 mobilizations in LD-CY group, the successful rate was 80.8%. For 10 mobilizations in the G-CSF group, the successful rate was 50%. The mean yield of CD34+ cells was higher in ID-CY/DOX and LD-CY groups as compared with that in G-CSF group (P = 0.026 and 0.020, respectively). There was no difference in the yield of CD34+ cells between ID-CY/DOX and LD-CY groups (P = 0.831). After autologous stem cell transplantation, the days to neutrophil and platelet engraftment were similar in these three groups (P = 0.713 and 0.821, respectively). In conclusion, we observed that ID-CY/DOX and LD-CY plus G-CSF for stem cell mobilization resulted in a higher successful rate and higher stem cell yields than G-CSF alone and their engraftment time were similar. Total WBC count >10 × 10(9) /L can be used as a guide to start apheresis in CY-based stem cell mobilization. J. Clin. Apheresis 31:423-428, 2016. © 2015 Wiley Periodicals, Inc.

Medienart:

E-Artikel

Erscheinungsjahr:

2016

Erschienen:

2016

Enthalten in:

Zur Gesamtaufnahme - volume:31

Enthalten in:

Journal of clinical apheresis - 31(2016), 5 vom: 04. Okt., Seite 423-8

Sprache:

Englisch

Beteiligte Personen:

Lin, Tung-Liang [VerfasserIn]
Wang, Po-Nan [VerfasserIn]
Kuo, Ming-Chung [VerfasserIn]
Hung, Yu-Hsing [VerfasserIn]
Chang, Hung [VerfasserIn]
Tang, Tzung-Chih [VerfasserIn]

Links:

Volltext

Themen:

143011-72-7
7S5I7G3JQL
80168379AG
8N3DW7272P
Antigens, CD34
Autologous hematopoietic stem cell transplantation
Cyclophosphamide
Dexamethasone
Doxorubicin
Granulocyte Colony-Stimulating Factor
Granulocyte-colony stimulating factor
Hematopoietic stem cell mobilization
Journal Article
Multiple myeloma

Anmerkungen:

Date Completed 03.04.2017

Date Revised 03.04.2017

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1002/jca.21421

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM252471369