Troponin in diabetic patients with and without chronic coronary artery disease
BACKGROUND: Cardiac-specific troponin detected with the new high-sensitivity assays can be chronically elevated in response to cardiovascular comorbidities and confer important prognostic information, in the absence of unstable coronary syndromes. Both diabetes mellitus and coronary artery disease are known predictors of troponin elevation. It is not known whether diabetic patients with coronary artery disease have different levels of troponin compared with diabetic patients with normal coronary arteries. To investigate this question, we determined the concentrations of a level 1 troponin assay in two groups of diabetic patients: those with multivessel coronary artery disease and those with angiographically normal coronary arteries.
METHODS: We studied 95 diabetic patients and compared troponin in serum samples from 50 patients with coronary artery disease (mean age = 63.7, 58 % male) with 45 controls with angiographically normal coronary arteries. Brain natriuretic peptide and the oxidative stress biomarkers myeloperoxidase, nitrotyrosine and oxidized LDL were also determined.
RESULTS: Diabetic patients with coronary artery disease had higher levels of troponin than did controls (median values, 12.0 pg/mL (95 % CI:10-16) vs 7.0 pg/mL (95 % CI: 5.9-8.5), respectively; p = 0.0001). The area under the ROC curve for the diagnosis of CAD was 0.712 with a sensitivity of 70 % and a specificity of 66 %. Plasma BNP levels and oxidative stress variables (myeloperoxidase, nitrotyrosine, and oxidized LDL) were not different between the two groups. In a multivariate analysis, gender (p = 0.04), serum glucose (0.03) and Troponin I (p = 0.01) had independent statistical significance.
CONCLUSION: Troponin elevation is related to the presence of chronic coronary artery disease in diabetic patients with multiple associated cardiovascular risk factors. Troponin may serve as a biomarker in this high-risk population.
TRIAL REGISTRATION: http://www.controlled-trials.com.
REGISTRATION NUMBER: ISRCTN26970041.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
BMC cardiovascular disorders - 15(2015) vom: 21. Juli, Seite 72 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Segre, Carlos Alexandre Wainrober [VerfasserIn] |
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| Links: |
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| Themen: |
114471-18-0 |
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| Anmerkungen: |
Date Completed 08.03.2016 Date Revised 13.11.2018 published: Electronic ISRCTN: ISRCTN26970041 Citation Status MEDLINE |
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| doi: |
10.1186/s12872-015-0051-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM251079309 |
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| 245 | 1 | 0 | |a Troponin in diabetic patients with and without chronic coronary artery disease |
| 264 | 1 | |c 2015 | |
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| 500 | |a Date Completed 08.03.2016 | ||
| 500 | |a Date Revised 13.11.2018 | ||
| 500 | |a published: Electronic | ||
| 500 | |a ISRCTN: ISRCTN26970041 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Cardiac-specific troponin detected with the new high-sensitivity assays can be chronically elevated in response to cardiovascular comorbidities and confer important prognostic information, in the absence of unstable coronary syndromes. Both diabetes mellitus and coronary artery disease are known predictors of troponin elevation. It is not known whether diabetic patients with coronary artery disease have different levels of troponin compared with diabetic patients with normal coronary arteries. To investigate this question, we determined the concentrations of a level 1 troponin assay in two groups of diabetic patients: those with multivessel coronary artery disease and those with angiographically normal coronary arteries | ||
| 520 | |a METHODS: We studied 95 diabetic patients and compared troponin in serum samples from 50 patients with coronary artery disease (mean age = 63.7, 58 % male) with 45 controls with angiographically normal coronary arteries. Brain natriuretic peptide and the oxidative stress biomarkers myeloperoxidase, nitrotyrosine and oxidized LDL were also determined | ||
| 520 | |a RESULTS: Diabetic patients with coronary artery disease had higher levels of troponin than did controls (median values, 12.0 pg/mL (95 % CI:10-16) vs 7.0 pg/mL (95 % CI: 5.9-8.5), respectively; p = 0.0001). The area under the ROC curve for the diagnosis of CAD was 0.712 with a sensitivity of 70 % and a specificity of 66 %. Plasma BNP levels and oxidative stress variables (myeloperoxidase, nitrotyrosine, and oxidized LDL) were not different between the two groups. In a multivariate analysis, gender (p = 0.04), serum glucose (0.03) and Troponin I (p = 0.01) had independent statistical significance | ||
| 520 | |a CONCLUSION: Troponin elevation is related to the presence of chronic coronary artery disease in diabetic patients with multiple associated cardiovascular risk factors. Troponin may serve as a biomarker in this high-risk population | ||
| 520 | |a TRIAL REGISTRATION: http://www.controlled-trials.com | ||
| 520 | |a REGISTRATION NUMBER: ISRCTN26970041 | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Rezende, Paulo Cury |e verfasserin |4 aut | |
| 700 | 1 | |a Favarato, Desiderio |e verfasserin |4 aut | |
| 700 | 1 | |a Strunz, Celia Maria Cassaro |e verfasserin |4 aut | |
| 700 | 1 | |a Sprandel, Marília da Costa Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Roggério, Alessandra |e verfasserin |4 aut | |
| 700 | 1 | |a Carvalho, Ana Luiza de Oliveira |e verfasserin |4 aut | |
| 700 | 1 | |a Maranhão, Raul Cavalcante |e verfasserin |4 aut | |
| 700 | 1 | |a Ramires, José Antonio Franchini |e verfasserin |4 aut | |
| 700 | 1 | |a Kalil Filho, Roberto |e verfasserin |4 aut | |
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