Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence
© The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com..
INTRODUCTION: Primate and rodent models show that peroxisome proliferator-activated receptor-alpha (PPAR-α) ligands, including fibrate medications, reduce nicotine reinforcement, reward, and related effects. We tested fenofibrate, the most common U.S. Food and Drug Administration-approved fibrate for lipid control versus placebo for initial evidence of efficacy in smoking cessation using a validated cross-over procedure for early Phase 2 evaluations.
METHODS: Adult dependent smokers (N = 38) in this 4-week within-subjects study were those already intending to try to quit in the next 2 months. All smoked ad libitum during weeks 1 (baseline) and 3 (washout) and began fenofibrate (160 mg/d; dosing approved for lipid control) or placebo near the end of weeks 1 and 3. Following each 4-day dose run-up, they were then instructed to try to quit for 4 days (Tuesday-Friday) during weeks 2 and 4, with the order of medication conditions counter-balanced and administered double-blind. Abstinence was verified daily in each 4-day quit period by self-report of no smoking in the prior 24 hours and carbon monoxide < 5 ppm. Secondary measures of acute smoking reinforcement and cue reactivity prior to quitting, and smoking reduction when trying to quit, were also assessed.
RESULTS: No differences between fenofibrate versus placebo were found on days quit (means ± SEM of 1.8±0.3 vs. 1.9±0.3, respectively). Similarly, there were no differences in any of the secondary measures (all P > .20).
CONCLUSIONS: Although higher dosing or other proliferator-activated receptor-alpha agonists may show efficacy, this study indicates that fenofibrate does not aid ability to stop smoking during a brief practice quit period in dependent smokers high in current quit interest.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2016 |
---|---|
Erschienen: |
2016 |
Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
---|---|
Enthalten in: |
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 18(2016), 1 vom: 21. Jan., Seite 74-8 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Perkins, Kenneth A [VerfasserIn] |
---|
Links: |
---|
Themen: |
7U1EE4V452 |
---|
Anmerkungen: |
Date Completed 21.07.2016 Date Revised 11.03.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1093/ntr/ntv085 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM248266225 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM248266225 | ||
003 | DE-627 | ||
005 | 20231224151028.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2016 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1093/ntr/ntv085 |2 doi | |
028 | 5 | 2 | |a pubmed24n0827.xml |
035 | |a (DE-627)NLM248266225 | ||
035 | |a (NLM)25895948 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Perkins, Kenneth A |e verfasserin |4 aut | |
245 | 1 | 0 | |a Initial Evaluation of Fenofibrate for Efficacy in Aiding Smoking Abstinence |
264 | 1 | |c 2016 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 21.07.2016 | ||
500 | |a Date Revised 11.03.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © The Author 2015. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissionsoup.com. | ||
520 | |a INTRODUCTION: Primate and rodent models show that peroxisome proliferator-activated receptor-alpha (PPAR-α) ligands, including fibrate medications, reduce nicotine reinforcement, reward, and related effects. We tested fenofibrate, the most common U.S. Food and Drug Administration-approved fibrate for lipid control versus placebo for initial evidence of efficacy in smoking cessation using a validated cross-over procedure for early Phase 2 evaluations | ||
520 | |a METHODS: Adult dependent smokers (N = 38) in this 4-week within-subjects study were those already intending to try to quit in the next 2 months. All smoked ad libitum during weeks 1 (baseline) and 3 (washout) and began fenofibrate (160 mg/d; dosing approved for lipid control) or placebo near the end of weeks 1 and 3. Following each 4-day dose run-up, they were then instructed to try to quit for 4 days (Tuesday-Friday) during weeks 2 and 4, with the order of medication conditions counter-balanced and administered double-blind. Abstinence was verified daily in each 4-day quit period by self-report of no smoking in the prior 24 hours and carbon monoxide < 5 ppm. Secondary measures of acute smoking reinforcement and cue reactivity prior to quitting, and smoking reduction when trying to quit, were also assessed | ||
520 | |a RESULTS: No differences between fenofibrate versus placebo were found on days quit (means ± SEM of 1.8±0.3 vs. 1.9±0.3, respectively). Similarly, there were no differences in any of the secondary measures (all P > .20) | ||
520 | |a CONCLUSIONS: Although higher dosing or other proliferator-activated receptor-alpha agonists may show efficacy, this study indicates that fenofibrate does not aid ability to stop smoking during a brief practice quit period in dependent smokers high in current quit interest | ||
650 | 4 | |a Clinical Trial, Phase II | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Randomized Controlled Trial | |
650 | 4 | |a Research Support, N.I.H., Extramural | |
650 | 7 | |a PPAR alpha |2 NLM | |
650 | 7 | |a Carbon Monoxide |2 NLM | |
650 | 7 | |a 7U1EE4V452 |2 NLM | |
650 | 7 | |a Fenofibrate |2 NLM | |
650 | 7 | |a U202363UOS |2 NLM | |
700 | 1 | |a Karelitz, Joshua L |e verfasserin |4 aut | |
700 | 1 | |a Michael, Valerie C |e verfasserin |4 aut | |
700 | 1 | |a Fromuth, Margaret |e verfasserin |4 aut | |
700 | 1 | |a Conklin, Cynthia A |e verfasserin |4 aut | |
700 | 1 | |a Chengappa, K N Roy |e verfasserin |4 aut | |
700 | 1 | |a Hope, Chris |e verfasserin |4 aut | |
700 | 1 | |a Lerman, Caryn |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco |d 1997 |g 18(2016), 1 vom: 21. Jan., Seite 74-8 |w (DE-627)NLM097536172 |x 1469-994X |7 nnns |
773 | 1 | 8 | |g volume:18 |g year:2016 |g number:1 |g day:21 |g month:01 |g pages:74-8 |
856 | 4 | 0 | |u http://dx.doi.org/10.1093/ntr/ntv085 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 18 |j 2016 |e 1 |b 21 |c 01 |h 74-8 |