The differential diagnosis and interdisciplinary treatment of anal carcinoma

BACKGROUND: Anal carcinoma accounts for 2-4% of all cases of colorectal and anorectal carcinoma. Its peak incidence is from age 58 to age 64; women are affected somewhat more commonly than men. Its incidence has risen markedly in the past three decades.

METHODS: This article is based on a selective review of the literature, including the guidelines of the National Comprehensive Cancer Network and the European Society of Medical Oncology.

RESULTS: Anal carcinoma is often an incidental finding. About 85% of newly diagnosed cases are associated with an HPV infection with strain 16, 18, or 33. Radiochemotherapy with 5-fluorouracil and mitomycin C is the treatment of choice. The 5-year survival rate is 80-90%. Primary surgery with curative intent is indicated only for well-differentiated carcinoma of the anal margin (T1, N0). 10-30% of patients now undergo radical resection. The utility of endosonography and positron emission tomography for staging is debated and needs further study.

CONCLUSION: The treatment of patients with anal carcinoma requires a specialized multidisciplinary approach in accordance with the current evidence-based guidelines. The potential role of prophylactic vaccination against oncogenic types of HPV in the prevention of anal carcinoma merits further investigation.

Errataetall:

CommentIn: Dtsch Arztebl Int. 2015 Oct 23;112(43):738. - PMID 26568181

Medienart:

E-Artikel

Erscheinungsjahr:

2015

Erschienen:

2015

Enthalten in:

Zur Gesamtaufnahme - volume:112

Enthalten in:

Deutsches Arzteblatt international - 112(2015), 14 vom: 03. Apr., Seite 243-9

Sprache:

Englisch

Beteiligte Personen:

Raptis, Dimitrios [VerfasserIn]
Schneider, Ignaz [VerfasserIn]
Matzel, Klaus E [VerfasserIn]
Ott, Oliver [VerfasserIn]
Fietkau, Rainer [VerfasserIn]
Hohenberger, Werner [VerfasserIn]

Links:

Volltext

Themen:

Journal Article
Review

Anmerkungen:

Date Completed 03.02.2016

Date Revised 13.11.2018

published: Print

CommentIn: Dtsch Arztebl Int. 2015 Oct 23;112(43):738. - PMID 26568181

Citation Status MEDLINE

doi:

10.3238/arztebl.2015.0243

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM248225774