The inflammasome in myocardial injury and cardiac remodeling
SIGNIFICANCE: An inflammatory response follows an injury of any nature, and while such a response is an attempt to promote healing, it may, itself, result in further injury.
RECENT ADVANCES: The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the injury and it amplifies the response by leading to the release of powerful pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18.
CRITICAL ISSUES: The activation of the inflammasome in the heart during ischemic and nonischemic injury represents an exaggerated response to sterile injury and promotes adverse cardiac remodeling and failure.
FUTURE DIRECTIONS: Pilot clinical trials have explored blockade of the inflammasome-derived IL-1β and have shown beneficial effects on cardiac function. Additional clinical studies testing this approach are warranted. Moreover, specific inflammasome inhibitors that are ready for clinical use are currently lacking.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2015 |
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| Erschienen: |
2015 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Antioxidants & redox signaling - 22(2015), 13 vom: 01. Mai, Seite 1146-61 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Toldo, Stefano [VerfasserIn] |
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| Links: |
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| Themen: |
Cytokines |
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| Anmerkungen: |
Date Completed 31.12.2015 Date Revised 16.04.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1089/ars.2014.5989 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM242924107 |
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| 245 | 1 | 4 | |a The inflammasome in myocardial injury and cardiac remodeling |
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| 500 | |a Date Revised 16.04.2015 | ||
| 500 | |a published: Print-Electronic | ||
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| 520 | |a SIGNIFICANCE: An inflammatory response follows an injury of any nature, and while such a response is an attempt to promote healing, it may, itself, result in further injury | ||
| 520 | |a RECENT ADVANCES: The inflammasome is a macromolecular structure recently recognized as a central mediator in the acute inflammatory response. The inflammasome senses the injury and it amplifies the response by leading to the release of powerful pro-inflammatory cytokines, interleukin-1β (IL-1β) and IL-18 | ||
| 520 | |a CRITICAL ISSUES: The activation of the inflammasome in the heart during ischemic and nonischemic injury represents an exaggerated response to sterile injury and promotes adverse cardiac remodeling and failure | ||
| 520 | |a FUTURE DIRECTIONS: Pilot clinical trials have explored blockade of the inflammasome-derived IL-1β and have shown beneficial effects on cardiac function. Additional clinical studies testing this approach are warranted. Moreover, specific inflammasome inhibitors that are ready for clinical use are currently lacking | ||
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| 700 | 1 | |a Salloum, Fadi |e verfasserin |4 aut | |
| 700 | 1 | |a Van Tassell, Benjamin Wallace |e verfasserin |4 aut | |
| 700 | 1 | |a Abbate, Antonio |e verfasserin |4 aut | |
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