Association of functional polymorphisms in FAS and FAS Ligand genes promoter with pre-eclampsia
© 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology..
AIM: Pre-eclampsia (PE) is a complex disorder of pregnancy with unknown etiology. FAS-mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FAS Ligand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS Ligand A-670G (rs1800682) and FAS Ligand C-844T (rs763110) gene polymorphisms with PE in southeast Iran.
METHODS: One hundred and twenty-seven unrelated women with PE and 139 healthy control subjects were genotyped for the FAS A-670G and FAS Ligand C-844T polymorphisms by polymerase chain reaction restriction fragment length polymorphism method.
RESULTS: The AA, AG and GG genotype frequency of the FAS A-670G polymorphism were 21.3%, 53.5% and 25.2% in pre-eclamptic women and 46.0%, 41.5% and 11.5% in controls and were statistically different (P = 0.0001). The risk of PE was 2.7- and 4.7-fold higher in pregnant women with AG and GG genotypes respectively. Although the frequency TT genotype and T allele of FAS Ligand C-844T gene polymorphism was higher in the PE group, the differences were not significant.
CONCLUSION: FAS A-670G polymorphism is associated with a higher risk for PE. There was no association between FAS Ligand C-844T polymorphism and PE.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2014 |
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| Erschienen: |
2014 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
The journal of obstetrics and gynaecology research - 40(2014), 5 vom: 29. Mai, Seite 1167-73 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Salimi, Saeedeh [VerfasserIn] |
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| Links: |
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| Themen: |
FAS |
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| Anmerkungen: |
Date Completed 19.05.2015 Date Revised 16.11.2017 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/jog.12327 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM236961276 |
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| 245 | 1 | 0 | |a Association of functional polymorphisms in FAS and FAS Ligand genes promoter with pre-eclampsia |
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| 500 | |a Date Revised 16.11.2017 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2014 The Authors. Journal of Obstetrics and Gynaecology Research © 2014 Japan Society of Obstetrics and Gynecology. | ||
| 520 | |a AIM: Pre-eclampsia (PE) is a complex disorder of pregnancy with unknown etiology. FAS-mediated apoptosis is assumed to prevent the development of PE; therefore FAS and FAS Ligand may be represented as candidate genes involved in PE pathogenesis. In the present study, we evaluated the relation between FAS Ligand A-670G (rs1800682) and FAS Ligand C-844T (rs763110) gene polymorphisms with PE in southeast Iran | ||
| 520 | |a METHODS: One hundred and twenty-seven unrelated women with PE and 139 healthy control subjects were genotyped for the FAS A-670G and FAS Ligand C-844T polymorphisms by polymerase chain reaction restriction fragment length polymorphism method | ||
| 520 | |a RESULTS: The AA, AG and GG genotype frequency of the FAS A-670G polymorphism were 21.3%, 53.5% and 25.2% in pre-eclamptic women and 46.0%, 41.5% and 11.5% in controls and were statistically different (P = 0.0001). The risk of PE was 2.7- and 4.7-fold higher in pregnant women with AG and GG genotypes respectively. Although the frequency TT genotype and T allele of FAS Ligand C-844T gene polymorphism was higher in the PE group, the differences were not significant | ||
| 520 | |a CONCLUSION: FAS A-670G polymorphism is associated with a higher risk for PE. There was no association between FAS Ligand C-844T polymorphism and PE | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a FAS | |
| 650 | 4 | |a FAS Ligand | |
| 650 | 4 | |a polymorphism | |
| 650 | 4 | |a pre-eclampsia | |
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| 700 | 1 | |a Tavilani, Heidar |e verfasserin |4 aut | |
| 700 | 1 | |a Hashemi, Mohammad |e verfasserin |4 aut | |
| 700 | 1 | |a Zand, Hamid |e verfasserin |4 aut | |
| 700 | 1 | |a Yaghmaei, Minoo |e verfasserin |4 aut | |
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