A pilot study comparing the effect of flaxseed, aromatase inhibitor, and the combination on breast tumor biomarkers

Use of complementary approaches is common among breast cancer survivors. Potential interactions between aromatase inhibitors (AI) and high phytoestrogen foods, such as flaxseed (FS), are not often described. We conducted a pilot 2 × 2 factorial, randomized intervention study between tumor biopsy and resection, in 24 postmenopausal women with estrogen receptor positive (ER+) breast cancer, to assess the effects of FS and anastrozole, and possible interactions between them, on serum steroid hormone and tumor-related characteristics associated with long-term survival (Roswell Park Cancer Institute, 2007-2010). The effect of each treatment vs. placebo on outcomes was determined by linear regression adjusting for pretreatment measure, stage, and grade. Although not statistically significant, mean ERβ expression was approximately 40% lower from pre- to postintervention in the FS + AI group only. We observed a statistically significant negative association (β ± SE -0.3 ± 0.1; P = 0.03) for androstenedione in the FS + AI group vs. placebo and for DHEA with AI treatment (β ± SE -1.6 ± 0.6; P = 0.009). Enterolactone excretion was much lower in the FS + AI group compared to the FS group. Our results do not support strong effects of FS on AI activity for selected breast tumor characteristics or serum steroid hormone levels but suggest AI therapy might reduce the production of circulating mammalian lignans from FS.

Medienart:

E-Artikel

Erscheinungsjahr:

2014

Erschienen:

2014

Enthalten in:

Zur Gesamtaufnahme - volume:66

Enthalten in:

Nutrition and cancer - 66(2014), 4 vom: 26., Seite 566-75

Sprache:

Englisch

Beteiligte Personen:

McCann, Susan E [VerfasserIn]
Edge, Stephen B [VerfasserIn]
Hicks, David G [VerfasserIn]
Thompson, Lilian U [VerfasserIn]
Morrison, Carl D [VerfasserIn]
Fetterly, Gerald [VerfasserIn]
Andrews, Christopher [VerfasserIn]
Clark, Kim [VerfasserIn]
Wilton, John [VerfasserIn]
Kulkarni, Swati [VerfasserIn]

Links:

Volltext

Themen:

2Z07MYW1AZ
Anastrozole
Aromatase Inhibitors
Biomarkers, Tumor
Estrogen Receptor beta
Gonadal Steroid Hormones
Journal Article
Lignans
Nitriles
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Triazoles

Anmerkungen:

Date Completed 22.12.2014

Date Revised 21.10.2021

published: Print-Electronic

ClinicalTrials.gov: NCT00612560

Citation Status MEDLINE

doi:

10.1080/01635581.2014.894097

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM236768611