Urinary neutrophil gelatinase-associated lipocalin levels predict cisplatin-induced acute kidney injury better than albuminuria or urinary cystatin C levels

Copyright © 2012. Published by Elsevier B.V..

Cisplatin-induced acute kidney injury (AKI) is a major concern among clinicians in prescribing cisplatin-based chemotherapy. This study evaluated and compared the ability of urinary biomarkers, including urinary neutrophil gelatinase-associated lipocalin (NGAL), cystatin C, and the urinary albumin to creatinine ratio (ACR) to predict cisplatin-induced AKI. Thirty-three cancer patients receiving cisplatin-based chemotherapy were prospectively studied, including 10 (30%) who developed AKI (the study group). Changes of urinary biomarkers were compared at 4 hours, 8 hours, and 12 hours, and 1 day, 2 days, 3 days, and 4 days after cisplatin intravenous infusions (75mg/m(2)) versus the baseline. There was a significant increase in urinary NGAL levels from 12 hours to 4 days (p<0.05) compared to baseline after cisplatin infusion in the AKI group. The magnitude of these changes over time differed significantly by group (p<0.001). The area under the receiver operating curve describing the relationship between urinary NGAL levels and AKI within 12 hours was 0.865 (95% confidence interval=0.691-1.000). Urinary NGAL levels independently predicted AKI 12 hours after cisplatin (p=0.045) after adjustments for age, gender, body mass index, baseline serum creatinine, and urinary total protein. Urinary NGAL levels may be an early biomarker of AKI in patients receiving cisplatin-based treatment.

Medienart:

E-Artikel

Erscheinungsjahr:

2013

Erschienen:

2013

Enthalten in:

Zur Gesamtaufnahme - volume:29

Enthalten in:

The Kaohsiung journal of medical sciences - 29(2013), 6 vom: 15. Juni, Seite 304-11

Sprache:

Englisch

Beteiligte Personen:

Lin, Hugo You-Hsien [VerfasserIn]
Lee, Su-Chu [VerfasserIn]
Lin, Sheng-Fung [VerfasserIn]
Hsiao, Hui-Hua [VerfasserIn]
Liu, Yi-Chang [VerfasserIn]
Yang, Wen-Chi [VerfasserIn]
Hwang, Daw-Yang [VerfasserIn]
Hung, Chi-Chih [VerfasserIn]
Chen, Hung-Chun [VerfasserIn]
Guh, Jinn-Yuh [VerfasserIn]

Links:

Volltext

Themen:

AYI8EX34EU
Acute-Phase Proteins
Cisplatin
Creatinine
Cystatin C
Journal Article
LCN2 protein, human
Lipocalin-2
Lipocalins
Proto-Oncogene Proteins
Q20Q21Q62J
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 10.07.2014

Date Revised 08.04.2022

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.kjms.2012.10.004

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM227594231