Chronic immune thrombocytopenia in children : who needs splenectomy?
Copyright © 2013 Elsevier Inc. All rights reserved..
In the field of emerging innovative therapies, such as thrombopoietin mimetics, the question of who needs splenectomy remains highly relevant. Removal of the spleen is an accepted and potentially curative treatment of immune thrombocytopenia (ITP) after decades with a favorable economical-effect ratio but with relevant morbidity particularly in the young patients. ITP is rare and splenectomy is performed in a minority of children, which makes its research almost impossible, resulting in a poor standardization of the procedure. Hence, in children, recommendation and decision for splenectomy is individually based and rests on expert opinions. Furthermore, local practice and availability of health products affect the frequency of splenectomy. Current guidelines agree on one point: splenectomy should be postponed for at least 12 months after the initial diagnosis of ITP, due to the high probability of improvement or even spontaneous remission. However, evidence-based data are lacking and splenectomy remains controversial. This article reviews the current literature and delineates controversies and complexities of splenectomy in children with ITP. There is an urgent need for consensus of this procedure in pediatric patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2013 |
|---|---|
| Erschienen: |
2013 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:50 Suppl 1 |
|---|---|
| Enthalten in: |
Seminars in hematology - 50 Suppl 1(2013) vom: 01. Jan., Seite S58-62 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Schifferli, Alexandra [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
|---|
| Anmerkungen: |
Date Completed 26.05.2014 Date Revised 13.05.2013 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1053/j.seminhematol.2013.03.010 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM227405307 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM227405307 | ||
| 003 | DE-627 | ||
| 005 | 20231224073634.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231224s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1053/j.seminhematol.2013.03.010 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n0758.xml |
| 035 | |a (DE-627)NLM227405307 | ||
| 035 | |a (NLM)23664519 | ||
| 035 | |a (PII)S0037-1963(13)00029-2 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Schifferli, Alexandra |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chronic immune thrombocytopenia in children |b who needs splenectomy? |
| 264 | 1 | |c 2013 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 26.05.2014 | ||
| 500 | |a Date Revised 13.05.2013 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2013 Elsevier Inc. All rights reserved. | ||
| 520 | |a In the field of emerging innovative therapies, such as thrombopoietin mimetics, the question of who needs splenectomy remains highly relevant. Removal of the spleen is an accepted and potentially curative treatment of immune thrombocytopenia (ITP) after decades with a favorable economical-effect ratio but with relevant morbidity particularly in the young patients. ITP is rare and splenectomy is performed in a minority of children, which makes its research almost impossible, resulting in a poor standardization of the procedure. Hence, in children, recommendation and decision for splenectomy is individually based and rests on expert opinions. Furthermore, local practice and availability of health products affect the frequency of splenectomy. Current guidelines agree on one point: splenectomy should be postponed for at least 12 months after the initial diagnosis of ITP, due to the high probability of improvement or even spontaneous remission. However, evidence-based data are lacking and splenectomy remains controversial. This article reviews the current literature and delineates controversies and complexities of splenectomy in children with ITP. There is an urgent need for consensus of this procedure in pediatric patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Kühne, Thomas |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Seminars in hematology |d 1964 |g 50 Suppl 1(2013) vom: 01. Jan., Seite S58-62 |w (DE-627)NLM000076481 |x 1532-8686 |7 nnns |
| 773 | 1 | 8 | |g volume:50 Suppl 1 |g year:2013 |g day:01 |g month:01 |g pages:S58-62 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1053/j.seminhematol.2013.03.010 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 50 Suppl 1 |j 2013 |b 01 |c 01 |h S58-62 | ||