Pro-inflammatory properties of cadmium

Cadmium is a toxic and carcinogenic heavy metal that nowadays constitutes a serious environmental health problem. The aim of this study is to review the effects of cadmium on selected inflammatory mediators and markers, such as NF-κB and AP-1 transcription factors, IL-6, TNF-α, IL-1β cytokines, IL-8 or MIP-2 chemokine, MPO, iNOS, MMPs and COX-2 enzymes, PGE(2) (product of COX-2 enzyme), ICAM-1, VCAM-1 and PECAM-1 adhesion molecules, and CRP. The research strategy identified articles available in Medline, published between 1998 and 2012; we included both in vivo and in vitro studies carried out on humans and rodents. Most of the reviewed research findings suggest that cadmium in micromolar concentrations (especially in the 1-10 μM range) causes up-regulation of the mediators and markers of inflammation, and appears to have pro-inflammatory properties. However, it is worth mentioning that a contradictory or even opposite hypothesis exists, which suggests cadmium to be an anti-inflammatory factor. Further research including detailed histological analyses should solve this discrepancy. Nevertheless, it appears that the main reason for these contradictory findings is the experimental setup: different biological systems analyzed and different doses of cadmium applied.

Medienart:

E-Artikel

Erscheinungsjahr:

2012

Erschienen:

2012

Enthalten in:

Zur Gesamtaufnahme - volume:59

Enthalten in:

Acta biochimica Polonica - 59(2012), 4 vom: 13., Seite 475-82

Sprache:

Englisch

Beteiligte Personen:

Olszowski, Tomasz [VerfasserIn]
Baranowska-Bosiacka, Irena [VerfasserIn]
Gutowska, Izabela [VerfasserIn]
Chlubek, Dariusz [VerfasserIn]

Themen:

00BH33GNGH
Anti-Inflammatory Agents
Biomarkers
Cadmium
Carcinogens, Environmental
Cytokines
Inflammation Mediators
Journal Article
Review

Anmerkungen:

Date Completed 13.06.2013

Date Revised 08.04.2022

published: Print-Electronic

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM223444812