Vitamin B-12 status during pregnancy and child's IQ at age 8 : a Mendelian randomization study in the Avon longitudinal study of parents and children
Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC). We then examined the association of SNPs in maternal genes FUT2 (rs492602) and TCN2 (rs1801198, rs9606756) that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child's IQ that was markedly attenuated after adjustment for potential confounders (mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 (95% CI 1.3, 2.8); after adjustment: 0.7 (95% CI -0.04, 1.4)). Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 (95% CI 0.1, 1.6). The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2012 |
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| Erschienen: |
2012 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:7 |
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| Enthalten in: |
PloS one - 7(2012), 12 vom: 01., Seite e51084 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bonilla, Carolina [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 21.05.2013 Date Revised 29.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1371/journal.pone.0051084 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM223324698 |
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| 100 | 1 | |a Bonilla, Carolina |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Vitamin B-12 status during pregnancy and child's IQ at age 8 |b a Mendelian randomization study in the Avon longitudinal study of parents and children |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Vitamin B-12 is essential for the development and maintenance of a healthy nervous system. Brain development occurs primarily in utero and early infancy, but the role of maternal vitamin B-12 status during pregnancy on offspring cognitive function is unclear. In this study we assessed the effect of vitamin B-12 status in well-nourished pregnant women on the cognitive ability of their offspring in a UK birth cohort (ALSPAC). We then examined the association of SNPs in maternal genes FUT2 (rs492602) and TCN2 (rs1801198, rs9606756) that are related to plasma vitamin B-12, with offspring IQ. Observationally, there was a positive association between maternal vitamin B-12 intake and child's IQ that was markedly attenuated after adjustment for potential confounders (mean difference in offspring IQ score per doubling of maternal B-12 intake, before adjustment: 2.0 (95% CI 1.3, 2.8); after adjustment: 0.7 (95% CI -0.04, 1.4)). Maternal FUT2 was weakly associated with offspring IQ: mean difference in IQ per allele was 0.9 (95% CI 0.1, 1.6). The expected effect of maternal vitamin B-12 on offspring IQ, given the relationships between SNPs and vitamin B-12, and SNPs and IQ was consistent with the observational result. Our findings suggest that maternal vitamin B-12 may not have an important effect on offspring cognitive ability. However, further examination of this issue is warranted | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a Vitamin B 12 |2 NLM | |
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| 700 | 1 | |a Lawlor, Debbie A |e verfasserin |4 aut | |
| 700 | 1 | |a Taylor, Amy E |e verfasserin |4 aut | |
| 700 | 1 | |a Gunnell, David J |e verfasserin |4 aut | |
| 700 | 1 | |a Ben-Shlomo, Yoav |e verfasserin |4 aut | |
| 700 | 1 | |a Ness, Andrew R |e verfasserin |4 aut | |
| 700 | 1 | |a Timpson, Nicholas J |e verfasserin |4 aut | |
| 700 | 1 | |a St Pourcain, Beate |e verfasserin |4 aut | |
| 700 | 1 | |a Ring, Susan M |e verfasserin |4 aut | |
| 700 | 1 | |a Emmett, Pauline M |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, A David |e verfasserin |4 aut | |
| 700 | 1 | |a Refsum, Helga |e verfasserin |4 aut | |
| 700 | 1 | |a Pennell, Craig E |e verfasserin |4 aut | |
| 700 | 1 | |a Brion, Marie-Jo |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, George Davey |e verfasserin |4 aut | |
| 700 | 1 | |a Lewis, Sarah J |e verfasserin |4 aut | |
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