Molecular strategies of microbial iron assimilation : from high-affinity complexes to cofactor assembly systems
Microorganisms have to cope with restricted iron bioavailability in most environmental habitats as well as during host colonization. The continuous struggle for iron has brought forth a plethora of acquisition and assimilation strategies that share several functional and mechanistic principles. One common theme is the utilization of high-affinity chelators for extracellular iron mobilization, generally known as siderophore-dependent iron acquisition. This basic strategy is related with another central aspect of microbial iron acquisition, which is the release of the mobilized iron from extracellular sources to allow its transfer and incorporation into metabolically active proteins. A variety of mechanisms which are often coupled with high-affinity uptake have evolved to facilitate the removal of iron from siderophore ligands; however, they differ in many key aspects including substrate specificities and release efficiencies. The most sophisticated iron release pathways comprise processes of specific hydrolysis and reduction of ferric siderophores, especially in the case of high-affinity iron complexes with greatly negative redox potentials that often represent crucial factors for virulence development in bacterial and fungal pathogens. During the following steps of iron utilization, the acquired metal is transferred through intracellular trafficking pathways which may include diverse storage compartments in order to be directed to cofactor assembly systems and to final protein targeting. Several of these iron channeling routes have been described recently and provide first insights into the later steps of iron assimilation that characterize an essential part of the cellular iron homeostasis network.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2013 |
---|---|
Erschienen: |
2013 |
Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
---|---|
Enthalten in: |
Metallomics : integrated biometal science - 5(2013), 1 vom: 21. Jan., Seite 15-28 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Miethke, Marcus [VerfasserIn] |
---|
Links: |
---|
Themen: |
Bacterial Proteins |
---|
Anmerkungen: |
Date Completed 28.05.2013 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
---|
doi: |
10.1039/c2mt20193c |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM222993960 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM222993960 | ||
003 | DE-627 | ||
005 | 20231224055642.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2013 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1039/c2mt20193c |2 doi | |
028 | 5 | 2 | |a pubmed24n0743.xml |
035 | |a (DE-627)NLM222993960 | ||
035 | |a (NLM)23192658 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Miethke, Marcus |e verfasserin |4 aut | |
245 | 1 | 0 | |a Molecular strategies of microbial iron assimilation |b from high-affinity complexes to cofactor assembly systems |
264 | 1 | |c 2013 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 28.05.2013 | ||
500 | |a Date Revised 21.11.2013 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Microorganisms have to cope with restricted iron bioavailability in most environmental habitats as well as during host colonization. The continuous struggle for iron has brought forth a plethora of acquisition and assimilation strategies that share several functional and mechanistic principles. One common theme is the utilization of high-affinity chelators for extracellular iron mobilization, generally known as siderophore-dependent iron acquisition. This basic strategy is related with another central aspect of microbial iron acquisition, which is the release of the mobilized iron from extracellular sources to allow its transfer and incorporation into metabolically active proteins. A variety of mechanisms which are often coupled with high-affinity uptake have evolved to facilitate the removal of iron from siderophore ligands; however, they differ in many key aspects including substrate specificities and release efficiencies. The most sophisticated iron release pathways comprise processes of specific hydrolysis and reduction of ferric siderophores, especially in the case of high-affinity iron complexes with greatly negative redox potentials that often represent crucial factors for virulence development in bacterial and fungal pathogens. During the following steps of iron utilization, the acquired metal is transferred through intracellular trafficking pathways which may include diverse storage compartments in order to be directed to cofactor assembly systems and to final protein targeting. Several of these iron channeling routes have been described recently and provide first insights into the later steps of iron assimilation that characterize an essential part of the cellular iron homeostasis network | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 4 | |a Review | |
650 | 7 | |a Bacterial Proteins |2 NLM | |
650 | 7 | |a Fungal Proteins |2 NLM | |
650 | 7 | |a Siderophores |2 NLM | |
650 | 7 | |a Iron |2 NLM | |
650 | 7 | |a E1UOL152H7 |2 NLM | |
773 | 0 | 8 | |i Enthalten in |t Metallomics : integrated biometal science |d 2009 |g 5(2013), 1 vom: 21. Jan., Seite 15-28 |w (DE-627)NLM19410088X |x 1756-591X |7 nnns |
773 | 1 | 8 | |g volume:5 |g year:2013 |g number:1 |g day:21 |g month:01 |g pages:15-28 |
856 | 4 | 0 | |u http://dx.doi.org/10.1039/c2mt20193c |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 5 |j 2013 |e 1 |b 21 |c 01 |h 15-28 |