Effects of donepezil on cognitive performance after sleep deprivation
Copyright © 2011 John Wiley & Sons, Ltd..
OBJECTIVES: To identify tasks that were sensitive to a temporary decline in cognitive performance after sleep deprivation and to investigate the ability of the acetylcholinesterase inhibitor donepezil to reverse any sleep deprivation-induced impairment.
METHODS: Thirty healthy volunteers were administered either a 5-mg daily dose of donepezil or placebo for 14-17 days, in a double-blind parallel group design, then underwent either 24 h sleep deprivation or a normal night of sleep in non-blinded crossover, and were subsequently tested on a battery of cognitive tasks designed to measure different components of memory and executive function.
RESULTS: Sleep deprivation selectively impaired performance on several memory tasks whilst also impairing non-memory function on these tasks. Performance on other tasks was spared. Despite partially reversing the decline in subjective alertness associated with sleep deprivation, treatment with donepezil failed to significantly reverse the decline in cognitive performance on any of the tasks.
CONCLUSIONS: The results demonstrate the sensitivity of certain tests, particularly those that measure memory function, to cognitive impairment after sleep deprivation. The inability of donepezil to reverse this performance decline suggests that the sleep deprivation model of cognitive impairment may not be suitable for detecting pro-cognitive effects of cholinergic augmentation.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2011 |
---|---|
Erschienen: |
2011 |
Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
---|---|
Enthalten in: |
Human psychopharmacology - 26(2011), 8 vom: 01. Dez., Seite 578-87 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Dodds, Chris M [VerfasserIn] |
---|
Links: |
---|
Themen: |
8SSC91326P |
---|
Anmerkungen: |
Date Completed 06.09.2012 Date Revised 29.01.2022 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.1002/hup.1248 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM213778785 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM213778785 | ||
003 | DE-627 | ||
005 | 20231224022250.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231224s2011 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1002/hup.1248 |2 doi | |
028 | 5 | 2 | |a pubmed24n0712.xml |
035 | |a (DE-627)NLM213778785 | ||
035 | |a (NLM)22161694 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Dodds, Chris M |e verfasserin |4 aut | |
245 | 1 | 0 | |a Effects of donepezil on cognitive performance after sleep deprivation |
264 | 1 | |c 2011 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 06.09.2012 | ||
500 | |a Date Revised 29.01.2022 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2011 John Wiley & Sons, Ltd. | ||
520 | |a OBJECTIVES: To identify tasks that were sensitive to a temporary decline in cognitive performance after sleep deprivation and to investigate the ability of the acetylcholinesterase inhibitor donepezil to reverse any sleep deprivation-induced impairment | ||
520 | |a METHODS: Thirty healthy volunteers were administered either a 5-mg daily dose of donepezil or placebo for 14-17 days, in a double-blind parallel group design, then underwent either 24 h sleep deprivation or a normal night of sleep in non-blinded crossover, and were subsequently tested on a battery of cognitive tasks designed to measure different components of memory and executive function | ||
520 | |a RESULTS: Sleep deprivation selectively impaired performance on several memory tasks whilst also impairing non-memory function on these tasks. Performance on other tasks was spared. Despite partially reversing the decline in subjective alertness associated with sleep deprivation, treatment with donepezil failed to significantly reverse the decline in cognitive performance on any of the tasks | ||
520 | |a CONCLUSIONS: The results demonstrate the sensitivity of certain tests, particularly those that measure memory function, to cognitive impairment after sleep deprivation. The inability of donepezil to reverse this performance decline suggests that the sleep deprivation model of cognitive impairment may not be suitable for detecting pro-cognitive effects of cholinergic augmentation | ||
650 | 4 | |a Comparative Study | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Randomized Controlled Trial | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 7 | |a Indans |2 NLM | |
650 | 7 | |a Piperidines |2 NLM | |
650 | 7 | |a Donepezil |2 NLM | |
650 | 7 | |a 8SSC91326P |2 NLM | |
700 | 1 | |a Bullmore, Edward T |e verfasserin |4 aut | |
700 | 1 | |a Henson, Richard N |e verfasserin |4 aut | |
700 | 1 | |a Christensen, Soren |e verfasserin |4 aut | |
700 | 1 | |a Miller, Sam |e verfasserin |4 aut | |
700 | 1 | |a Smith, Marie |e verfasserin |4 aut | |
700 | 1 | |a Dewit, Odile |e verfasserin |4 aut | |
700 | 1 | |a Lawrence, Phil |e verfasserin |4 aut | |
700 | 1 | |a Nathan, Pradeep J |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Human psychopharmacology |d 1995 |g 26(2011), 8 vom: 01. Dez., Seite 578-87 |w (DE-627)NLM086748149 |x 1099-1077 |7 nnns |
773 | 1 | 8 | |g volume:26 |g year:2011 |g number:8 |g day:01 |g month:12 |g pages:578-87 |
856 | 4 | 0 | |u http://dx.doi.org/10.1002/hup.1248 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 26 |j 2011 |e 8 |b 01 |c 12 |h 578-87 |