The variance of melphalan doses related to kilogram of body weight and the consequences
Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in several observations. BSA-based dosing leads to significant variability in doses administered per kilogram of body weight (mg/kg), contributes to increased oral toxicity and probably does not have any significant effect on treatment results within equally BSA (mg/m2) dosed melphalan regimens.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2010 |
|---|---|
| Erschienen: |
2010 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
|---|---|
| Enthalten in: |
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti - 23(2010), 6 vom: 31., Seite 452-3 |
| Sprache: |
Tschechisch |
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| Weiterer Titel: |
Variabilita dávek melfalanu vztazených na kilogram telesné hmotnosti a následky |
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| Beteiligte Personen: |
Vokurka, S [VerfasserIn] |
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| Themen: |
Antineoplastic Agents, Alkylating |
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| Anmerkungen: |
Date Completed 14.03.2011 Date Revised 21.11.2013 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM206147546 |
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| 245 | 1 | 4 | |a The variance of melphalan doses related to kilogram of body weight and the consequences |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Melphalan is an important cytotoxic drug. The empirical practice of body surface area-based (BSA) dosing (mg/m2) of melphalan has been critically analyzed in several observations. BSA-based dosing leads to significant variability in doses administered per kilogram of body weight (mg/kg), contributes to increased oral toxicity and probably does not have any significant effect on treatment results within equally BSA (mg/m2) dosed melphalan regimens | ||
| 650 | 4 | |a English Abstract | |
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