Serum concentrations of interleukin-6 in patients following unilateral versus bilateral total knee arthroplasty
BACKGROUND: Surgical stress is known to affect body temperature, white blood cell (WBC) count, C-reactive protein (CRP), and interleukin-6 (IL-6). The aim of the present study was to investigate which parameter is most suitable for quantitative analysis of surgical stress.
METHODS: Unilateral total knee arthroplasty (U-TKA) and bilateral TKA (B-TKA) were selected for the subjects of this study because the B-TKA creates approximately double the surgical stress of the U-TKA. The temperature, WBC count, CRP, and IL-6 in the blood were measured pre- and postoperatively in both groups. The IL-6 in the drainage fluid was also measured after the operation.
RESULTS: The temperature, WBC count, CRP, and IL-6 in the blood significantly increased on the first day after the operation in both groups. There were significant differences between the two groups in the WBC count (P < 0.05) and the IL-6 level in the blood (P < 0.05) on the first day after the surgery. There were no significant differences between the two groups for the CRP and IL-6 levels in the drainage fluid. The relative proportions--(B-TKA/U-TKA) x 100 (%)--were 170.4% for the operating time, 219.4 % for total blood loss, 200.0% for blood transfusion, 100.3% for temperature, 128.9% for WBC count, 127.4% for CRP, and 246.5% for the IL-6 level in the blood.
CONCLUSIONS: The serum IL-6 level may best reflect surgical stress and could therefore be a quantitative marker of surgical stress.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2009 |
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| Erschienen: |
2009 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association - 14(2009), 4 vom: 14. Juli, Seite 437-42 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kugisaki, Hajime [VerfasserIn] |
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| Links: |
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| Themen: |
9007-41-4 |
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| Anmerkungen: |
Date Completed 02.11.2009 Date Revised 19.11.2015 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00776-009-1344-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM190521724 |
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| 100 | 1 | |a Kugisaki, Hajime |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Serum concentrations of interleukin-6 in patients following unilateral versus bilateral total knee arthroplasty |
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| 500 | |a Date Completed 02.11.2009 | ||
| 500 | |a Date Revised 19.11.2015 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Surgical stress is known to affect body temperature, white blood cell (WBC) count, C-reactive protein (CRP), and interleukin-6 (IL-6). The aim of the present study was to investigate which parameter is most suitable for quantitative analysis of surgical stress | ||
| 520 | |a METHODS: Unilateral total knee arthroplasty (U-TKA) and bilateral TKA (B-TKA) were selected for the subjects of this study because the B-TKA creates approximately double the surgical stress of the U-TKA. The temperature, WBC count, CRP, and IL-6 in the blood were measured pre- and postoperatively in both groups. The IL-6 in the drainage fluid was also measured after the operation | ||
| 520 | |a RESULTS: The temperature, WBC count, CRP, and IL-6 in the blood significantly increased on the first day after the operation in both groups. There were significant differences between the two groups in the WBC count (P < 0.05) and the IL-6 level in the blood (P < 0.05) on the first day after the surgery. There were no significant differences between the two groups for the CRP and IL-6 levels in the drainage fluid. The relative proportions--(B-TKA/U-TKA) x 100 (%)--were 170.4% for the operating time, 219.4 % for total blood loss, 200.0% for blood transfusion, 100.3% for temperature, 128.9% for WBC count, 127.4% for CRP, and 246.5% for the IL-6 level in the blood | ||
| 520 | |a CONCLUSIONS: The serum IL-6 level may best reflect surgical stress and could therefore be a quantitative marker of surgical stress | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Biomarkers |2 NLM | |
| 650 | 7 | |a Interleukin-6 |2 NLM | |
| 650 | 7 | |a C-Reactive Protein |2 NLM | |
| 650 | 7 | |a 9007-41-4 |2 NLM | |
| 700 | 1 | |a Sonohata, Motoki |e verfasserin |4 aut | |
| 700 | 1 | |a Komine, Mitsunori |e verfasserin |4 aut | |
| 700 | 1 | |a Tsunoda, Kenji |e verfasserin |4 aut | |
| 700 | 1 | |a Someya, Shinsuke |e verfasserin |4 aut | |
| 700 | 1 | |a Honke, Hidefumi |e verfasserin |4 aut | |
| 700 | 1 | |a Mawatari, Masaaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hotokebuchi, Takao |e verfasserin |4 aut | |
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