Differential effects of nitric oxide on rod and cone pathways in carp retina
The effects of nitric oxide (NO) on electroretinograms and light responses of horizontal cells intracellularly recorded from isolated, superfused carp retinas were studied. Sodium nitroprusside (SNP), an NO donor, suppressed scotopic b wave, while enhancing photopic b wave, and the effects could be blocked by hemoglobin, an NO chelator. Furthermore, following SNP application, light responses of rod horizontal cells were reduced in size and those of cone horizontal cells were increased. These results suggest that NO suppresses the activity of rod pathway, but enhances that of cone pathway in the outer retina. Moreover, the effects of methylene blue, an inhibitor of soluble guanylate cyclase, on rod and cone horizontal cells were just opposite to those of SNP, implying that the effects of NO may be mediated by cGMP.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1997 |
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| Erschienen: |
1997 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Science in China. Series C, Life sciences - 40(1997), 1 vom: 07. Feb., Seite 71-8 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ye, B [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 14.07.2011 Date Revised 20.10.2016 published: Print Citation Status PubMed-not-MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM181801183 |
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| 100 | 1 | |a Ye, B |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Differential effects of nitric oxide on rod and cone pathways in carp retina |
| 264 | 1 | |c 1997 | |
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| 500 | |a Date Completed 14.07.2011 | ||
| 500 | |a Date Revised 20.10.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a The effects of nitric oxide (NO) on electroretinograms and light responses of horizontal cells intracellularly recorded from isolated, superfused carp retinas were studied. Sodium nitroprusside (SNP), an NO donor, suppressed scotopic b wave, while enhancing photopic b wave, and the effects could be blocked by hemoglobin, an NO chelator. Furthermore, following SNP application, light responses of rod horizontal cells were reduced in size and those of cone horizontal cells were increased. These results suggest that NO suppresses the activity of rod pathway, but enhances that of cone pathway in the outer retina. Moreover, the effects of methylene blue, an inhibitor of soluble guanylate cyclase, on rod and cone horizontal cells were just opposite to those of SNP, implying that the effects of NO may be mediated by cGMP | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Yang, X |e verfasserin |4 aut | |
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