Urocortin's inhibition of tumor growth and angiogenesis in hepatocellular carcinoma via corticotrophin-releasing factor receptor 2
Urocortin (UCN) functions via corticotrophin-releasing factor receptors (CRFRs), CRFR1 & 2. CRFR2 is reported to be a tonic suppressor of vascularization, implying its role in tumor angiogenesis. Here, it was found that UCN inhibited the growth of hepatocellular carcinoma (HCC) and reduced tumor microvessel density in nude mice. Hepatoma cells didn't express CRFRs whereas vessels expressed CRFRs, mainly CRFR2. In vitro three-dimensional culture assay showed UCN inhibited angiogenesis, this effect was abolished by CRFR2 antagonist, anti-sauvagine-30, demonstrating involvement of CRFR2. Furthermore, UCN inhibited the proliferation and promoted the apoptosis of endothelial cells and down-regulated VEGF expression in vivo via CRFR2.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2008 |
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| Erschienen: |
2008 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Cancer investigation - 26(2008), 4 vom: 29. Mai, Seite 359-68 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wang, Juejin [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 02.06.2008 Date Revised 29.04.2008 published: Print Citation Status MEDLINE |
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| doi: |
10.1080/07357900701788106 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM179228145 |
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| 245 | 1 | 0 | |a Urocortin's inhibition of tumor growth and angiogenesis in hepatocellular carcinoma via corticotrophin-releasing factor receptor 2 |
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| 500 | |a Date Completed 02.06.2008 | ||
| 500 | |a Date Revised 29.04.2008 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Urocortin (UCN) functions via corticotrophin-releasing factor receptors (CRFRs), CRFR1 & 2. CRFR2 is reported to be a tonic suppressor of vascularization, implying its role in tumor angiogenesis. Here, it was found that UCN inhibited the growth of hepatocellular carcinoma (HCC) and reduced tumor microvessel density in nude mice. Hepatoma cells didn't express CRFRs whereas vessels expressed CRFRs, mainly CRFR2. In vitro three-dimensional culture assay showed UCN inhibited angiogenesis, this effect was abolished by CRFR2 antagonist, anti-sauvagine-30, demonstrating involvement of CRFR2. Furthermore, UCN inhibited the proliferation and promoted the apoptosis of endothelial cells and down-regulated VEGF expression in vivo via CRFR2 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a CRF receptor type 2 |2 NLM | |
| 650 | 7 | |a Neoplasm Proteins |2 NLM | |
| 650 | 7 | |a Receptors, Corticotropin-Releasing Hormone |2 NLM | |
| 650 | 7 | |a Urocortins |2 NLM | |
| 650 | 7 | |a VEGFA protein, human |2 NLM | |
| 650 | 7 | |a Vascular Endothelial Growth Factor A |2 NLM | |
| 650 | 7 | |a vascular endothelial growth factor A, mouse |2 NLM | |
| 700 | 1 | |a Xu, Youhua |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Yinyan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Huayuan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Rongjian |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Guoxin |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Shengnan |e verfasserin |4 aut | |
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