Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains : synthesis and biological evaluation
A series of mono-1H-benzo[c,d]indol-2-one with different amine side chains and bis-1H-benzo[c,d]indol-2-one as novel family of DNA intercalators were designed and synthesized, the contributions of aromatic chromophores and amine side chains for DNA binding properties, for example, intercalation and electrostatic binding, respectively, were evaluated. Among them, A3 tailed with N,N-dimethylamino-ethyl-ethane-1,2-diamine showed selective anti-tumor activities against cell lines A549 and P388 with IC(50) 0.428microm and 1.69microm.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2007 |
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| Erschienen: |
2007 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Bioorganic & medicinal chemistry - 15(2007), 3 vom: 01. Feb., Seite 1356-62 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yin, Hong [VerfasserIn] |
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| Themen: |
9007-49-2 |
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| Anmerkungen: |
Date Completed 05.04.2007 Date Revised 08.01.2007 published: Print-Electronic Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM166821101 |
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| 245 | 1 | 0 | |a Novel antitumor agent family of 1H-benzo[c,d]indol-2-one with flexible basic side chains |b synthesis and biological evaluation |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A series of mono-1H-benzo[c,d]indol-2-one with different amine side chains and bis-1H-benzo[c,d]indol-2-one as novel family of DNA intercalators were designed and synthesized, the contributions of aromatic chromophores and amine side chains for DNA binding properties, for example, intercalation and electrostatic binding, respectively, were evaluated. Among them, A3 tailed with N,N-dimethylamino-ethyl-ethane-1,2-diamine showed selective anti-tumor activities against cell lines A549 and P388 with IC(50) 0.428microm and 1.69microm | ||
| 650 | 4 | |a Journal Article | |
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