The protean immune cell synapse : a supramolecular structure with many functions
Heterogeneity in the supramolecular organization of immunological synapses arises from the involvement of different cells, distinct environmental stimuli, and varying levels of protein expression. There may also be heterogeneity in the types and amounts of cell surface proteins and lipids that transfer between lymphocytes during immune surveillance. In addition, immune cells can be involved in the assembly of a 'viral synapse', such that micrometer-scale organization of proteins at intercellular contacts occurs during transmission of a virus between T cells. Thus, while there may be unity in molecular mechanisms underlying the organization of cell surface receptors at immune cell synapses, there is diversity in their function.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2003 |
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| Erschienen: |
2003 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:15 |
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| Enthalten in: |
Seminars in immunology - 15(2003), 6 vom: 02. Dez., Seite 317-24 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Davis, Daniel M [VerfasserIn] |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 31.03.2004 Date Revised 15.11.2006 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Davis, Daniel M |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The protean immune cell synapse |b a supramolecular structure with many functions |
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| 500 | |a Date Completed 31.03.2004 | ||
| 500 | |a Date Revised 15.11.2006 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Heterogeneity in the supramolecular organization of immunological synapses arises from the involvement of different cells, distinct environmental stimuli, and varying levels of protein expression. There may also be heterogeneity in the types and amounts of cell surface proteins and lipids that transfer between lymphocytes during immune surveillance. In addition, immune cells can be involved in the assembly of a 'viral synapse', such that micrometer-scale organization of proteins at intercellular contacts occurs during transmission of a virus between T cells. Thus, while there may be unity in molecular mechanisms underlying the organization of cell surface receptors at immune cell synapses, there is diversity in their function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Receptors, Immunologic |2 NLM | |
| 700 | 1 | |a Igakura, Tadahiko |e verfasserin |4 aut | |
| 700 | 1 | |a McCann, Fiona E |e verfasserin |4 aut | |
| 700 | 1 | |a Carlin, Leo M |e verfasserin |4 aut | |
| 700 | 1 | |a Andersson, Katja |e verfasserin |4 aut | |
| 700 | 1 | |a Vanherberghen, Bruno |e verfasserin |4 aut | |
| 700 | 1 | |a Sjöström, Anna |e verfasserin |4 aut | |
| 700 | 1 | |a Bangham, Charles R M |e verfasserin |4 aut | |
| 700 | 1 | |a Höglund, Petter |e verfasserin |4 aut | |
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