Inositol 1,4,5-trisphosphate receptor/Ca(2+) channel modulatory role of chromogranins A and B
The secretory granules function as the major IP(3)-sensitive intracellular Ca(2+) store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca(2+) channels and high-capacity, low-affinity Ca(2+) storage proteins chromogranins A (CgA) and B (CgB). The IP(3)R/Ca(2+) channel was shown to directly interact with CgA and CgB at the intragranular pH 5.5, and this coupling led to modulation of the IP(3)R/Ca(2+) channel activity by the coupled chromogranins. These results provide the molecular structural basis of the IP(3)-mediated Ca(2+) release mechanism of secretory granules.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2002 |
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| Erschienen: |
2002 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:971 |
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| Enthalten in: |
Annals of the New York Academy of Sciences - 971(2002) vom: 26. Okt., Seite 300-10 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yoo, Seung Hyun [VerfasserIn] |
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| Themen: |
Calcium Channels |
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| Anmerkungen: |
Date Completed 16.12.2002 Date Revised 16.06.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM122244931 |
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| 100 | 1 | |a Yoo, Seung Hyun |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Inositol 1,4,5-trisphosphate receptor/Ca(2+) channel modulatory role of chromogranins A and B |
| 264 | 1 | |c 2002 | |
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| 500 | |a Date Completed 16.12.2002 | ||
| 500 | |a Date Revised 16.06.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The secretory granules function as the major IP(3)-sensitive intracellular Ca(2+) store of secretory cells. Recently it was found that the secretory granules contain three isoforms of inositol 1,4,5-trisphosphate receptor (IP(3)R)/Ca(2+) channels and high-capacity, low-affinity Ca(2+) storage proteins chromogranins A (CgA) and B (CgB). The IP(3)R/Ca(2+) channel was shown to directly interact with CgA and CgB at the intragranular pH 5.5, and this coupling led to modulation of the IP(3)R/Ca(2+) channel activity by the coupled chromogranins. These results provide the molecular structural basis of the IP(3)-mediated Ca(2+) release mechanism of secretory granules | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 7 | |a Calcium Channels |2 NLM | |
| 650 | 7 | |a Chromogranin A |2 NLM | |
| 650 | 7 | |a Chromogranins |2 NLM | |
| 650 | 7 | |a Inositol 1,4,5-Trisphosphate Receptors |2 NLM | |
| 650 | 7 | |a Protein Isoforms |2 NLM | |
| 650 | 7 | |a Receptors, Cytoplasmic and Nuclear |2 NLM | |
| 700 | 1 | |a So, Seung Ho |e verfasserin |4 aut | |
| 700 | 1 | |a Huh, Yang Hoon |e verfasserin |4 aut | |
| 700 | 1 | |a Park, Hee Yun |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of the New York Academy of Sciences |d 1945 |g 971(2002) vom: 26. Okt., Seite 300-10 |w (DE-627)NLM000012823 |x 1749-6632 |7 nnns |
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