MRI investigation of hydration and heterogeneous degradation of aliphatic polyesters derived from lactic and glycolic acids : a controlled drug delivery device
Magnetic Resonance Imaging experiments have been used to investigate the degradation of drug-loaded poly(glycolic lactic acid) (PGLA) 50:50 cylinders. Spatial variation in the rate of degradation throughout the polymer cross-section has been observed non-invasively using quantitative imaging of penetrant concentration, T(2) and self-diffusion coefficient. This spatial variation in the rate of degradation was attributed to the quicker degradation in the inner region of the sample due to autocatalysis by carboxyl end groups generated upon ester bond cleavage.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2001 |
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| Erschienen: |
2001 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
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| Enthalten in: |
Magnetic resonance imaging - 19(2001), 3-4 vom: 27. Apr., Seite 521-3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Djemai, A [VerfasserIn] |
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| Themen: |
059QF0KO0R |
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| Anmerkungen: |
Date Completed 23.08.2001 Date Revised 06.09.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM113481128 |
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| 245 | 1 | 0 | |a MRI investigation of hydration and heterogeneous degradation of aliphatic polyesters derived from lactic and glycolic acids |b a controlled drug delivery device |
| 264 | 1 | |c 2001 | |
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| 500 | |a Date Completed 23.08.2001 | ||
| 500 | |a Date Revised 06.09.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Magnetic Resonance Imaging experiments have been used to investigate the degradation of drug-loaded poly(glycolic lactic acid) (PGLA) 50:50 cylinders. Spatial variation in the rate of degradation throughout the polymer cross-section has been observed non-invasively using quantitative imaging of penetrant concentration, T(2) and self-diffusion coefficient. This spatial variation in the rate of degradation was attributed to the quicker degradation in the inner region of the sample due to autocatalysis by carboxyl end groups generated upon ester bond cleavage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Drug Carriers |2 NLM | |
| 650 | 7 | |a Glycolates |2 NLM | |
| 650 | 7 | |a Polyesters |2 NLM | |
| 650 | 7 | |a Water |2 NLM | |
| 650 | 7 | |a 059QF0KO0R |2 NLM | |
| 650 | 7 | |a glycolic acid |2 NLM | |
| 650 | 7 | |a 0WT12SX38S |2 NLM | |
| 650 | 7 | |a Lactic Acid |2 NLM | |
| 650 | 7 | |a 33X04XA5AT |2 NLM | |
| 700 | 1 | |a Gladden, L F |e verfasserin |4 aut | |
| 700 | 1 | |a Booth, J |e verfasserin |4 aut | |
| 700 | 1 | |a Kittlety, R S |e verfasserin |4 aut | |
| 700 | 1 | |a Gellert, P R |e verfasserin |4 aut | |
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