Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infection
Viral infections are characterised by a large expansion of CD8+ effector T cells. Once generated, these T cells must be cleared and homeostasis re-established. In this review we describe two mechanisms, apoptosis and replicative senescence which are thought to play a vital role in this process. Apoptosis clears the unwanted T cells at the end of an immune response whereas replicative senescence prevents unlimited expansion of T cells. For successful memory to be produced T cells must avoid apoptosis and avoid replicative senescence.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2000 |
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| Erschienen: |
2000 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:5 |
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| Enthalten in: |
Apoptosis : an international journal on programmed cell death - 5(2000), 5 vom: 08. Nov., Seite 431-4 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Plunkett, F J [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 29.03.2001 Date Revised 04.11.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM111674492 |
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| 100 | 1 | |a Plunkett, F J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Regulation of apoptosis and replicative senescence in CD8+ T cell following acute viral infection |
| 264 | 1 | |c 2000 | |
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| 500 | |a Date Completed 29.03.2001 | ||
| 500 | |a Date Revised 04.11.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Viral infections are characterised by a large expansion of CD8+ effector T cells. Once generated, these T cells must be cleared and homeostasis re-established. In this review we describe two mechanisms, apoptosis and replicative senescence which are thought to play a vital role in this process. Apoptosis clears the unwanted T cells at the end of an immune response whereas replicative senescence prevents unlimited expansion of T cells. For successful memory to be produced T cells must avoid apoptosis and avoid replicative senescence | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Soares, M V |e verfasserin |4 aut | |
| 700 | 1 | |a Salmon, M |e verfasserin |4 aut | |
| 700 | 1 | |a Akbar, A N |e verfasserin |4 aut | |
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