Sleep changes induced by lipopolysaccharide in the rat are influenced by age

In mammals, aging is associated with immune senescense. To examine whether the sleep changes occurring during immune challenge are affected by age, we assessed sleep alterations induced by the administration of lipopolysaccharide (LPS) in young and middle-aged rats. During vehicle, the middle-aged rats exhibited less pre-rapid eye movement sleep (pre-REMS) as well as REMS, due to a smaller number and shorter duration of REMS episodes, than young rats. LPS elevated body temperature, increased non-REMS, and suppressed both pre-REMS and REMS in the young as well as in the middle-aged rats. However, in the young animals, LPS significantly enhanced slow-wave activity in the electroencephalogram (EEG) within non-REMS, reflecting an increase in sleep intensity. In contrast, LPS attenuated EEG power in most frequency bands in the older animals. This finding indicates age-related changes in the modulation of sleep by LPS.

Medienart:

Artikel

Erscheinungsjahr:

2001

Erschienen:

2001

Enthalten in:

Zur Gesamtaufnahme - volume:280

Enthalten in:

American journal of physiology. Regulatory, integrative and comparative physiology - 280(2001), 2 vom: 18. Feb., Seite R398-403

Sprache:

Englisch

Beteiligte Personen:

Schiffelholz, T [VerfasserIn]
Lancel, M [VerfasserIn]

Themen:

Comparative Study
Journal Article
Lipopolysaccharides

Anmerkungen:

Date Completed 12.04.2001

Date Revised 30.09.2020

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM111204100