Captopril MR renography in a swine model : toward a comprehensive evaluation of renal arterial stenosis

PURPOSE: To test the feasibility of captopril magnetic resonance (MR) renography and to validate the technique in an animal model of renal arterial stenosis.

MATERIALS AND METHODS: Seven pigs with induced renal arterial stenosis were studied. MR renography was performed with a T1-weighted approach by using three-dimensional fast imaging with steady-state precession, or FISP, sequences after administration of a bolus of 0.1 mmol of gadopentetate dimeglumine per kilogram of body weight. Captopril was administered to improve the specificity.

RESULTS: The results demonstrate that differences in renographic curves and indices are observed only if an anatomically substantial stenosis, typically a diameter reduction of more than 70%, is present and captopril is administered.

CONCLUSION: In this preliminary experience in an animal model, captopril MR renography provided data consistent with expectations based on conventional renographic results.

Medienart:

Artikel

Erscheinungsjahr:

2000

Erschienen:

2000

Enthalten in:

Zur Gesamtaufnahme - volume:217

Enthalten in:

Radiology - 217(2000), 3 vom: 09. Dez., Seite 813-8

Sprache:

Englisch

Beteiligte Personen:

Prasad, P V [VerfasserIn]
Goldfarb, J [VerfasserIn]
Sundaram, C [VerfasserIn]
Priatna, A [VerfasserIn]
Li, W [VerfasserIn]
Edelman, R R [VerfasserIn]

Themen:

Angiotensin-Converting Enzyme Inhibitors
Evaluation Study
Journal Article

Anmerkungen:

Date Completed 11.01.2001

Date Revised 10.12.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM110260767