An analysis of meiotic impairment and of sex chromosome associations throughout meiosis in XYY mice
Copyright 2000 S. Karger AG, Basel..
The existing XYY meiotic data for mice present a very heterogeneous picture with respect to the relative frequencies of different sex chromosome associations, both at pachytene and diakinesis/metaphase I. Furthermore, where both pachytene and diakinesis/MI data are available for the same males, the frequencies of the different configurations at the two stages are very different. In the present paper we utilise "XYY" and "XY/XYY" mosaic mice with cytologically distinguishable Y chromosomes to investigate the factors responsible for this heterogeneity between different males and between the two meiotic stages. It is concluded (1) that the initial pattern of synapsis is driven by the relatedness of the three pseudoautosomal regions (PARs); (2) that the order and extent of PAR synapsis within radial trivalents are also affected by PAR relatedness and that this leads to chiasmata being preferentially formed between closely related PARs; (3) that trivalents with a single chiasma resolve into a bivalent + univalent by the diakinesis stage; (4) that although many spermatocytes with asynapsed sex chromosomes are eliminated between pachytene and diakinesis, those that survive this phase of elimination progress to the first meiotic metaphase (MI) and accumulate in large numbers, leading to an over-representation of those with univalents as compared to radial trivalents; and (5) that the arrested MI cells are eventually eliminated, so that very few "XYY" cells contribute products to MII.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2000 |
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| Erschienen: |
2000 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:89 |
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| Enthalten in: |
Cytogenetics and cell genetics - 89(2000), 1-2 vom: 20., Seite 29-37 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Mahadevaiah, S K [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 09.08.2000 Date Revised 01.11.2017 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Mahadevaiah, S K |e verfasserin |4 aut | |
| 245 | 1 | 3 | |a An analysis of meiotic impairment and of sex chromosome associations throughout meiosis in XYY mice |
| 264 | 1 | |c 2000 | |
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| 500 | |a Date Completed 09.08.2000 | ||
| 500 | |a Date Revised 01.11.2017 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright 2000 S. Karger AG, Basel. | ||
| 520 | |a The existing XYY meiotic data for mice present a very heterogeneous picture with respect to the relative frequencies of different sex chromosome associations, both at pachytene and diakinesis/metaphase I. Furthermore, where both pachytene and diakinesis/MI data are available for the same males, the frequencies of the different configurations at the two stages are very different. In the present paper we utilise "XYY" and "XY/XYY" mosaic mice with cytologically distinguishable Y chromosomes to investigate the factors responsible for this heterogeneity between different males and between the two meiotic stages. It is concluded (1) that the initial pattern of synapsis is driven by the relatedness of the three pseudoautosomal regions (PARs); (2) that the order and extent of PAR synapsis within radial trivalents are also affected by PAR relatedness and that this leads to chiasmata being preferentially formed between closely related PARs; (3) that trivalents with a single chiasma resolve into a bivalent + univalent by the diakinesis stage; (4) that although many spermatocytes with asynapsed sex chromosomes are eliminated between pachytene and diakinesis, those that survive this phase of elimination progress to the first meiotic metaphase (MI) and accumulate in large numbers, leading to an over-representation of those with univalents as compared to radial trivalents; and (5) that the arrested MI cells are eventually eliminated, so that very few "XYY" cells contribute products to MII | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Burgoyne, P S |e verfasserin |4 aut | |
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