Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation
Three clustered mouse chemokine genes, ABCD-1, -2 and -3, are all expressed highly in dendritic cells and, at various levels, in activated B cells. T cell-independently activated B cells express ABCD-1 and -2, but not -3. T cell-dependently activated B cells express all three. ABCD-1 attracts activated CD8+ cytotoxic T cells and CD4+ helper T cells of type 1 and 2. ABCD-2 preferentially attracts type 2 helper T cells, while ABCD-3 does not attract T cells at all. Both ABCD-1 and ABCD-2 bind to the same receptor (CCR4). In addition, ABCD-1 binds to a second, unknown, receptor on a separate T cell population. The three chemokines might guide T cell-independent as well as -dependent responses with two types of CD4+ T cells.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1999 |
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| Erschienen: |
1999 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
European journal of immunology - 29(1999), 9 vom: 01. Sept., Seite 2934-47 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Schaniel, C [VerfasserIn] |
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| Anmerkungen: |
Date Completed 26.10.1999 Date Revised 24.04.2018 published: Print GENBANK: AF125570, AF125571, AF125572 Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM104390417 |
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| 100 | 1 | |a Schaniel, C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Three chemokines with potential functions in T lymphocyte-independent and -dependent B lymphocyte stimulation |
| 264 | 1 | |c 1999 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 26.10.1999 | ||
| 500 | |a Date Revised 24.04.2018 | ||
| 500 | |a published: Print | ||
| 500 | |a GENBANK: AF125570, AF125571, AF125572 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Three clustered mouse chemokine genes, ABCD-1, -2 and -3, are all expressed highly in dendritic cells and, at various levels, in activated B cells. T cell-independently activated B cells express ABCD-1 and -2, but not -3. T cell-dependently activated B cells express all three. ABCD-1 attracts activated CD8+ cytotoxic T cells and CD4+ helper T cells of type 1 and 2. ABCD-2 preferentially attracts type 2 helper T cells, while ABCD-3 does not attract T cells at all. Both ABCD-1 and ABCD-2 bind to the same receptor (CCR4). In addition, ABCD-1 binds to a second, unknown, receptor on a separate T cell population. The three chemokines might guide T cell-independent as well as -dependent responses with two types of CD4+ T cells | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 7 | |a CCL17 protein, human |2 NLM | |
| 650 | 7 | |a CCL22 protein, human |2 NLM | |
| 650 | 7 | |a CX3CL1 protein, human |2 NLM | |
| 650 | 7 | |a Ccl17 protein, mouse |2 NLM | |
| 650 | 7 | |a Ccl22 protein, mouse |2 NLM | |
| 650 | 7 | |a Chemokine CCL17 |2 NLM | |
| 650 | 7 | |a Chemokine CCL22 |2 NLM | |
| 650 | 7 | |a Chemokine CX3CL1 |2 NLM | |
| 650 | 7 | |a Chemokines, CC |2 NLM | |
| 650 | 7 | |a Chemokines, CX3C |2 NLM | |
| 650 | 7 | |a Cx3cl1 protein, mouse |2 NLM | |
| 650 | 7 | |a Membrane Proteins |2 NLM | |
| 650 | 7 | |a RNA, Messenger |2 NLM | |
| 700 | 1 | |a Sallusto, F |e verfasserin |4 aut | |
| 700 | 1 | |a Ruedl, C |e verfasserin |4 aut | |
| 700 | 1 | |a Sideras, P |e verfasserin |4 aut | |
| 700 | 1 | |a Melchers, F |e verfasserin |4 aut | |
| 700 | 1 | |a Rolink, A G |e verfasserin |4 aut | |
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| 951 | |a AR | ||
| 952 | |d 29 |j 1999 |e 9 |b 01 |c 09 |h 2934-47 | ||