Changes in the expression of alpha- and beta-myosin heavy chain gene during the development of renal hypertension in rats

The changes in the expression of cardiac alpha- and beta-myosin heavy chain (MHC) gene of the left ventricle were investigated in two-kidney, one-clip (2K1C) renal hypertensive rats. The results were as follows: (1) When blood pressure was increased, the left ventricle became hypertrophic, alpha-MHC gene expression was reduced and beta-MHC gene expression was increased in 2K1C renal hypertensive rats. (2) When the animal was treated with captopril, angiotensin converting enzyme inhibitor 4 W after operation and then 8 W with removal of the ischemic kidney, the blood pressure was decreased with attendant regression of left ventricular hypertrophy, while the increase in beta-MHC mRNA level was attenuated and the inhibition of alpha-MHC mRNA level was reduced. The above results suggest that the rise in arteral pressure is an important factor in the left ventricular hypertrophy and the MHC gene switch. Renin angiotension system may be involved in the cardiac hypertrophic and MHC gene switch during the development and maintenance of 2K1C renal hypertension.

Medienart:

Artikel

Erscheinungsjahr:

1997

Erschienen:

1997

Enthalten in:

Zur Gesamtaufnahme - volume:49

Enthalten in:

Sheng li xue bao : [Acta physiologica Sinica - 49(1997), 3 vom: 30. Juni, Seite 344-8

Sprache:

Chinesisch

Beteiligte Personen:

Zheng, H [VerfasserIn]
Pan, J Y [VerfasserIn]
Li, H Y [VerfasserIn]
Zhou, X N [VerfasserIn]

Themen:

9G64RSX1XD
Angiotensin-Converting Enzyme Inhibitors
Captopril
EC 3.6.4.1
English Abstract
Journal Article
Myosin Heavy Chains
Research Support, Non-U.S. Gov't

Anmerkungen:

Date Completed 16.12.1998

Date Revised 21.11.2013

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM097507105