Des-gamma-carboxy prothrombin and alpha-fetoprotein positive status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma
BACKGROUND: The aim of this study was to elucidate the usefulness of measuring the positive status of both des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) preoperatively as a new prognostic indicator of hepatocellular carcinoma (HCC).
METHODS: One hundred forty-seven patients who underwent curative hepatic resection for primary HCC were studied. The definitions of DCP and AFP positivity were: positive DCP > 0.1 AU/ml, and positive AFP > 50 ng/ml. The patients were classified into four groups according to their levels of positivity for DCP and/or AFP: Group 1 (n = 59), negative levels of both DCP and AFP; Group 2 (n = 28), negative DCP and positive AFP levels; Group 3 (n = 31), positive DCP and negative AFP levels; and Group 4 (n = 29), positive levels of both DCP and AFP.
RESULTS: Patient survival and disease free survival in Group 4 were the worst among the four groups. By multivariate analysis, using Cox proportional hazards model, both the DCP- and AFP-positive status (in combination) and poorly differentiated histology were independent factors of poor prognosis for patient survival; and DCP- and AFP-positive status (in combination), poorly differentiated histology, positive intrahepatic metastasis, and tumor diameter over 5 cm were independent factors of poor prognosis for disease free survival.
CONCLUSIONS: The combination of DCP- and AFP-positive status is a new prognostic indicator for patients with HCC after hepatic resection.
Medienart: |
Artikel |
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Erscheinungsjahr: |
1996 |
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Erschienen: |
1996 |
Enthalten in: |
Zur Gesamtaufnahme - volume:78 |
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Enthalten in: |
Cancer - 78(1996), 10 vom: 15. Nov., Seite 2094-100 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Shimada, M [VerfasserIn] |
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Themen: |
53230-14-1 |
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Anmerkungen: |
Date Completed 17.12.1996 Date Revised 30.03.2022 published: Print Citation Status MEDLINE |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM08885437X |
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041 | |a eng | ||
100 | 1 | |a Shimada, M |e verfasserin |4 aut | |
245 | 1 | 0 | |a Des-gamma-carboxy prothrombin and alpha-fetoprotein positive status as a new prognostic indicator after hepatic resection for hepatocellular carcinoma |
264 | 1 | |c 1996 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
338 | |a Band |b nc |2 rdacarrier | ||
500 | |a Date Completed 17.12.1996 | ||
500 | |a Date Revised 30.03.2022 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a BACKGROUND: The aim of this study was to elucidate the usefulness of measuring the positive status of both des-gamma-carboxy prothrombin (DCP) and alpha-fetoprotein (AFP) preoperatively as a new prognostic indicator of hepatocellular carcinoma (HCC) | ||
520 | |a METHODS: One hundred forty-seven patients who underwent curative hepatic resection for primary HCC were studied. The definitions of DCP and AFP positivity were: positive DCP > 0.1 AU/ml, and positive AFP > 50 ng/ml. The patients were classified into four groups according to their levels of positivity for DCP and/or AFP: Group 1 (n = 59), negative levels of both DCP and AFP; Group 2 (n = 28), negative DCP and positive AFP levels; Group 3 (n = 31), positive DCP and negative AFP levels; and Group 4 (n = 29), positive levels of both DCP and AFP | ||
520 | |a RESULTS: Patient survival and disease free survival in Group 4 were the worst among the four groups. By multivariate analysis, using Cox proportional hazards model, both the DCP- and AFP-positive status (in combination) and poorly differentiated histology were independent factors of poor prognosis for patient survival; and DCP- and AFP-positive status (in combination), poorly differentiated histology, positive intrahepatic metastasis, and tumor diameter over 5 cm were independent factors of poor prognosis for disease free survival | ||
520 | |a CONCLUSIONS: The combination of DCP- and AFP-positive status is a new prognostic indicator for patients with HCC after hepatic resection | ||
650 | 4 | |a Journal Article | |
650 | 7 | |a Biomarkers |2 NLM | |
650 | 7 | |a Biomarkers, Tumor |2 NLM | |
650 | 7 | |a Protein Precursors |2 NLM | |
650 | 7 | |a alpha-Fetoproteins |2 NLM | |
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700 | 1 | |a Takenaka, K |e verfasserin |4 aut | |
700 | 1 | |a Fujiwara, Y |e verfasserin |4 aut | |
700 | 1 | |a Gion, T |e verfasserin |4 aut | |
700 | 1 | |a Kajiyama, K |e verfasserin |4 aut | |
700 | 1 | |a Maeda, T |e verfasserin |4 aut | |
700 | 1 | |a Shirabe, K |e verfasserin |4 aut | |
700 | 1 | |a Sugimachi, K |e verfasserin |4 aut | |
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