Growth hormone normalizes hepatic lipase in hypothyroid rat liver
The effects of growth hormone (GH) administration on hepatic lipase (HL) activity and mRNA levels were studied in pair-fed hypothyroid rats. In the hypothyroid state, liver HL mRNA levels and liver and postheparin plasma HL activities were decreased. In hypothyroid rats, GH normalized HL mRNA levels and HL activity in postheparin plasma; GH also increased the activity of HL in the liver, which remained lower than that in controls. These data indicate that at least part of the decrease of HL activity during hypothyroidism is due to the concomitant GH deficiency, and that GH rather than thyroid hormone may regulate HL mRNA levels.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1993 |
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| Erschienen: |
1993 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Metabolism: clinical and experimental - 42(1993), 6 vom: 05. Juni, Seite 669-71 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hoogerbrugge, N [VerfasserIn] |
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| Themen: |
67763-96-6 |
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| Anmerkungen: |
Date Completed 09.07.1993 Date Revised 25.07.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM084849339 |
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| 100 | 1 | |a Hoogerbrugge, N |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Growth hormone normalizes hepatic lipase in hypothyroid rat liver |
| 264 | 1 | |c 1993 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
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| 500 | |a Date Completed 09.07.1993 | ||
| 500 | |a Date Revised 25.07.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The effects of growth hormone (GH) administration on hepatic lipase (HL) activity and mRNA levels were studied in pair-fed hypothyroid rats. In the hypothyroid state, liver HL mRNA levels and liver and postheparin plasma HL activities were decreased. In hypothyroid rats, GH normalized HL mRNA levels and HL activity in postheparin plasma; GH also increased the activity of HL in the liver, which remained lower than that in controls. These data indicate that at least part of the decrease of HL activity during hypothyroidism is due to the concomitant GH deficiency, and that GH rather than thyroid hormone may regulate HL mRNA levels | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a RNA, Messenger |2 NLM | |
| 650 | 7 | |a Insulin-Like Growth Factor I |2 NLM | |
| 650 | 7 | |a 67763-96-6 |2 NLM | |
| 650 | 7 | |a Growth Hormone |2 NLM | |
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| 650 | 7 | |a Lipase |2 NLM | |
| 650 | 7 | |a EC 3.1.1.3 |2 NLM | |
| 700 | 1 | |a Jansen, H |e verfasserin |4 aut | |
| 700 | 1 | |a Staels, B |e verfasserin |4 aut | |
| 700 | 1 | |a Seip, M J |e verfasserin |4 aut | |
| 700 | 1 | |a Birkenhäger, J C |e verfasserin |4 aut | |
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