Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2)
Abnormalities due to chromosomal aberration or point mutation in gene products of growth factor receptors or in ras gene products, which lie on the same signaling pathway, can cause disease in animals and humans. Thus, it can be important to determine chromosomal map positions of genes encoding "adapter" proteins, which are involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as ras, because adaptor protein genes could also, logically, serve as targets of mutation, rearrangement, or other aberration in disease. Therefore, DNAs from panels of rodent-human hybrids carrying defined complements of human chromosomes were assayed for the presence of the cognate genes for NCK, SHC, and GRB2, three SH2 or SH2/SH3 (Src homology 2 and 3) domain-containing adapter proteins. Additionally, NCK and SHC genes were more narrowly localized by chromosomal in situ hybridization. The NCK locus is at chromosome region 3q21, a region involved in neoplasia-associated changes; the SHC cognate locus, SHC1, is at 1q21, and the GRB2 locus is at 17q22-qter telomeric to the HOXB and NGFR loci. Both SHC1 and GRB2 are in chromosome regions that may be duplicated in some tumor types.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1994 |
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| Erschienen: |
1994 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Genomics - 22(1994), 2 vom: 15. Juli, Seite 281-7 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Huebner, K [VerfasserIn] |
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| Anmerkungen: |
Date Completed 30.01.1995 Date Revised 04.09.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM077818296 |
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| 100 | 1 | |a Huebner, K |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Chromosome locations of genes encoding human signal transduction adapter proteins, Nck (NCK), Shc (SHC1), and Grb2 (GRB2) |
| 264 | 1 | |c 1994 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 30.01.1995 | ||
| 500 | |a Date Revised 04.09.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Abnormalities due to chromosomal aberration or point mutation in gene products of growth factor receptors or in ras gene products, which lie on the same signaling pathway, can cause disease in animals and humans. Thus, it can be important to determine chromosomal map positions of genes encoding "adapter" proteins, which are involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as ras, because adaptor protein genes could also, logically, serve as targets of mutation, rearrangement, or other aberration in disease. Therefore, DNAs from panels of rodent-human hybrids carrying defined complements of human chromosomes were assayed for the presence of the cognate genes for NCK, SHC, and GRB2, three SH2 or SH2/SH3 (Src homology 2 and 3) domain-containing adapter proteins. Additionally, NCK and SHC genes were more narrowly localized by chromosomal in situ hybridization. The NCK locus is at chromosome region 3q21, a region involved in neoplasia-associated changes; the SHC cognate locus, SHC1, is at 1q21, and the GRB2 locus is at 17q22-qter telomeric to the HOXB and NGFR loci. Both SHC1 and GRB2 are in chromosome regions that may be duplicated in some tumor types | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Adaptor Proteins, Signal Transducing |2 NLM | |
| 650 | 7 | |a Adaptor Proteins, Vesicular Transport |2 NLM | |
| 650 | 7 | |a GRB2 Adaptor Protein |2 NLM | |
| 650 | 7 | |a GRB2 protein, human |2 NLM | |
| 650 | 7 | |a Grb2 protein, mouse |2 NLM | |
| 650 | 7 | |a Nck protein |2 NLM | |
| 650 | 7 | |a Oncogene Proteins |2 NLM | |
| 650 | 7 | |a Proteins |2 NLM | |
| 650 | 7 | |a SHC1 protein, human |2 NLM | |
| 650 | 7 | |a Shc Signaling Adaptor Proteins |2 NLM | |
| 650 | 7 | |a Shc1 protein, mouse |2 NLM | |
| 650 | 7 | |a Src Homology 2 Domain-Containing, Transforming Protein 1 |2 NLM | |
| 700 | 1 | |a Kastury, K |e verfasserin |4 aut | |
| 700 | 1 | |a Druck, T |e verfasserin |4 aut | |
| 700 | 1 | |a Salcini, A E |e verfasserin |4 aut | |
| 700 | 1 | |a Lanfrancone, L |e verfasserin |4 aut | |
| 700 | 1 | |a Pelicci, G |e verfasserin |4 aut | |
| 700 | 1 | |a Lowenstein, E |e verfasserin |4 aut | |
| 700 | 1 | |a Li, W |e verfasserin |4 aut | |
| 700 | 1 | |a Park, S H |e verfasserin |4 aut | |
| 700 | 1 | |a Cannizzaro, L |e verfasserin |4 aut | |
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