Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP
The three dimensional solution structure of the carboxy terminal LIM domain of the avian Cysteine Rich Protein (CRP) has been determined by nuclear magnetic resonance spectroscopy. The domain contains two zinc atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules. Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules pack due to hydrophobic interactions forming a novel global fold. The structure of the C-terminal CCCC module is essentially identical to that observed for the DNA-interactive CCCC modules of the GATA-1 and steroid hormone receptor DNA binding domains, raising the possibility that the LIM motif may have a DNA binding function.
| Errataetall: |
CommentIn: Nat Struct Biol. 1994 Jun;1(6):345-9. - PMID 7664042 |
|---|---|
| Medienart: |
Artikel |
| Erscheinungsjahr: |
1994 |
|---|---|
| Erschienen: |
1994 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:1 |
|---|---|
| Enthalten in: |
Nature structural biology - 1(1994), 6 vom: 22. Juni, Seite 388-98 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Pérez-Alvarado, G C [VerfasserIn] |
|---|
| Themen: |
9007-49-2 |
|---|
| Anmerkungen: |
Date Completed 10.10.1995 Date Revised 16.03.2022 published: Print CommentIn: Nat Struct Biol. 1994 Jun;1(6):345-9. - PMID 7664042 Citation Status MEDLINE |
|---|
| Förderinstitution / Projekttitel: |
|
|---|
| PPN (Katalog-ID): |
NLM076400425 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM076400425 | ||
| 003 | DE-627 | ||
| 005 | 20231222031310.0 | ||
| 007 | tu | ||
| 008 | 231222s1994 xx ||||| 00| ||eng c | ||
| 028 | 5 | 2 | |a pubmed24n0255.xml |
| 035 | |a (DE-627)NLM076400425 | ||
| 035 | |a (NLM)7664053 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Pérez-Alvarado, G C |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP |
| 264 | 1 | |c 1994 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 10.10.1995 | ||
| 500 | |a Date Revised 16.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Nat Struct Biol. 1994 Jun;1(6):345-9. - PMID 7664042 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The three dimensional solution structure of the carboxy terminal LIM domain of the avian Cysteine Rich Protein (CRP) has been determined by nuclear magnetic resonance spectroscopy. The domain contains two zinc atoms bound independently in CCHC (C = Cys, H = His) and CCCC modules. Both modules contain two orthogonally-arranged antiparallel beta-sheets, and the CCCC module contains an alpha-helix at its C terminus. The modules pack due to hydrophobic interactions forming a novel global fold. The structure of the C-terminal CCCC module is essentially identical to that observed for the DNA-interactive CCCC modules of the GATA-1 and steroid hormone receptor DNA binding domains, raising the possibility that the LIM motif may have a DNA binding function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Avian Proteins |2 NLM | |
| 650 | 7 | |a Muscle Proteins |2 NLM | |
| 650 | 7 | |a Proto-Oncogene Proteins c-myc |2 NLM | |
| 650 | 7 | |a cysteine-rich protein, avian |2 NLM | |
| 650 | 7 | |a DNA |2 NLM | |
| 650 | 7 | |a 9007-49-2 |2 NLM | |
| 700 | 1 | |a Miles, C |e verfasserin |4 aut | |
| 700 | 1 | |a Michelsen, J W |e verfasserin |4 aut | |
| 700 | 1 | |a Louis, H A |e verfasserin |4 aut | |
| 700 | 1 | |a Winge, D R |e verfasserin |4 aut | |
| 700 | 1 | |a Beckerle, M C |e verfasserin |4 aut | |
| 700 | 1 | |a Summers, M F |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature structural biology |d 1994 |g 1(1994), 6 vom: 22. Juni, Seite 388-98 |w (DE-627)NLM07514588X |x 1072-8368 |7 nnns |
| 773 | 1 | 8 | |g volume:1 |g year:1994 |g number:6 |g day:22 |g month:06 |g pages:388-98 |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 1 |j 1994 |e 6 |b 22 |c 06 |h 388-98 | ||