Autopsy report of acute necrotizing opticomyelopathy associated with thyroid cancer

We report an autopsied case of paraneoplastic necrotizing myelopathy. The patient had bilateral blindness, quadriplegia, and dyspnea of acute onset and died without remission 7 weeks later. The severe tissue necrosis and demyelination were found in the optic chiasm and from the medulla oblongata throughout the whole length of spinal cord. A papillary carcinoma was found in the thyroid gland at autopsy. In the present case IgG, myelin basic protein and activated helper T cells were increased in the CSF at onset, suggesting a mechanism of autoimmune demyelination for the condition.

Medienart:

Artikel

Erscheinungsjahr:

1993

Erschienen:

1993

Enthalten in:

Zur Gesamtaufnahme - volume:120

Enthalten in:

Journal of the neurological sciences - 120(1993), 1 vom: 01. Dez., Seite 29-32

Sprache:

Englisch

Beteiligte Personen:

Kuroda, Y [VerfasserIn]
Miyahara, M [VerfasserIn]
Sakemi, T [VerfasserIn]
Matsui, M [VerfasserIn]
Ryu, T [VerfasserIn]
Yamaguchi, M [VerfasserIn]
Sasadomi, E [VerfasserIn]
Sugihara, H [VerfasserIn]

Themen:

Case Reports
Immunoglobulin G
Journal Article
Myelin Basic Protein

Anmerkungen:

Date Completed 22.02.1994

Date Revised 24.07.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM074834088