Prelabeling of chimeric monoclonal antibody L6 with 90yttrium- and 111indium-1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA) chelates for radioimmunodiagnosis and therapy
90Y and 111In have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate). The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody. Studies in human patients showed excellent 111In single-photon emission computed tomography images of breast cancer lesions 24 h after injection.
| Medienart: |
Artikel |
|---|
| Erscheinungsjahr: |
1995 |
|---|---|
| Erschienen: |
1995 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
|---|---|
| Enthalten in: |
Cancer research - 55(1995), 23 Suppl vom: 01. Dez., Seite 5726s-5728s |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Li, M [VerfasserIn] |
|---|
| Anmerkungen: |
Date Completed 11.01.1996 Date Revised 23.11.2016 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM074699865 |
|---|
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| 041 | |a eng | ||
| 100 | 1 | |a Li, M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Prelabeling of chimeric monoclonal antibody L6 with 90yttrium- and 111indium-1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA) chelates for radioimmunodiagnosis and therapy |
| 264 | 1 | |c 1995 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 11.01.1996 | ||
| 500 | |a Date Revised 23.11.2016 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a 90Y and 111In have been attached to chimeric monoclonal antibody L6 with a bifunctional chelating agent (DOTA-peptide isothiocyanate). The bifunctional chelating agent was prelabeled with either radiometal and then conjugated to the antibody. Studies in human patients showed excellent 111In single-photon emission computed tomography images of breast cancer lesions 24 h after injection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, P.H.S. | |
| 650 | 7 | |a Antibodies, Bispecific |2 NLM | |
| 650 | 7 | |a Antibodies, Monoclonal |2 NLM | |
| 650 | 7 | |a Antibodies, Neoplasm |2 NLM | |
| 650 | 7 | |a Heterocyclic Compounds |2 NLM | |
| 650 | 7 | |a Heterocyclic Compounds, 1-Ring |2 NLM | |
| 650 | 7 | |a Indium Radioisotopes |2 NLM | |
| 650 | 7 | |a Yttrium Radioisotopes |2 NLM | |
| 650 | 7 | |a 1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid |2 NLM | |
| 650 | 7 | |a 1HTE449DGZ |2 NLM | |
| 700 | 1 | |a Meares, C F |e verfasserin |4 aut | |
| 700 | 1 | |a Salako, Q |e verfasserin |4 aut | |
| 700 | 1 | |a Kukis, D L |e verfasserin |4 aut | |
| 700 | 1 | |a Zhong, G R |e verfasserin |4 aut | |
| 700 | 1 | |a Miers, L |e verfasserin |4 aut | |
| 700 | 1 | |a DeNardo, S J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cancer research |d 1945 |g 55(1995), 23 Suppl vom: 01. Dez., Seite 5726s-5728s |w (DE-627)NLM000001740 |x 1538-7445 |7 nnns |
| 773 | 1 | 8 | |g volume:55 |g year:1995 |g number:23 Suppl |g day:01 |g month:12 |g pages:5726s-5728s |
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| 952 | |d 55 |j 1995 |e 23 Suppl |b 01 |c 12 |h 5726s-5728s | ||