Role of antigen and antibody in the regulation of the immune response
The enzyme dextranase could degrade antigenic dextran in vivo even when given 6-15 d after the antigen. Dextranase injected after the antigen suppressed the immune response when given 24 but not 48 h after the antigen, indicating that the antigen must interact with the immune system for 48 h to initiate a response. Thereafter, the B cells are independent of further antigen stimulation. To show whether antibody-mediated suppression of the immune response was determinant specific FITC-conjugated SRC were applied as immunogen and antibodies were raised both against the carrier (SRC) and the FITC hapten. When these antibodies were injected 1-3 h after the immunogen they only suppressed the immune response to the corresponding determinant. Anti-carrier antibodies usually enhanced the response to the hapten. Therefore, antibody-mediated suppression of the immune response is determinant-specific and cannot be mediated in vivo to a detectable extent by the Fc part of the antibodies.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
1985 |
|---|---|
| Erschienen: |
1985 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
|---|---|
| Enthalten in: |
Folia microbiologica - 30(1985), 3 vom: 01., Seite 203-11 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Möller, G [VerfasserIn] |
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| Themen: |
Antibodies |
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| Anmerkungen: |
Date Completed 22.08.1985 Date Revised 28.08.2019 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM023903155 |
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| 100 | 1 | |a Möller, G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Role of antigen and antibody in the regulation of the immune response |
| 264 | 1 | |c 1985 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ohne Hilfsmittel zu benutzen |b n |2 rdamedia | ||
| 338 | |a Band |b nc |2 rdacarrier | ||
| 500 | |a Date Completed 22.08.1985 | ||
| 500 | |a Date Revised 28.08.2019 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The enzyme dextranase could degrade antigenic dextran in vivo even when given 6-15 d after the antigen. Dextranase injected after the antigen suppressed the immune response when given 24 but not 48 h after the antigen, indicating that the antigen must interact with the immune system for 48 h to initiate a response. Thereafter, the B cells are independent of further antigen stimulation. To show whether antibody-mediated suppression of the immune response was determinant specific FITC-conjugated SRC were applied as immunogen and antibodies were raised both against the carrier (SRC) and the FITC hapten. When these antibodies were injected 1-3 h after the immunogen they only suppressed the immune response to the corresponding determinant. Anti-carrier antibodies usually enhanced the response to the hapten. Therefore, antibody-mediated suppression of the immune response is determinant-specific and cannot be mediated in vivo to a detectable extent by the Fc part of the antibodies | ||
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Antibodies |2 NLM | |
| 650 | 7 | |a Antigens |2 NLM | |
| 650 | 7 | |a Dextrans |2 NLM | |
| 650 | 7 | |a Epitopes |2 NLM | |
| 650 | 7 | |a Fluoresceins |2 NLM | |
| 650 | 7 | |a Thiocyanates |2 NLM | |
| 650 | 7 | |a Dextranase |2 NLM | |
| 650 | 7 | |a EC 3.2.1.11 |2 NLM | |
| 650 | 7 | |a Fluorescein-5-isothiocyanate |2 NLM | |
| 650 | 7 | |a I223NX31W9 |2 NLM | |
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| 773 | 1 | 8 | |g volume:30 |g year:1985 |g number:3 |g day:01 |g pages:203-11 |
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