Hemophan versus hemophan--a philippic against the suggestion of constant membrane quality

All statements referring to biocompatibility of dialyzers depend on the suggestion of a constant and reproducible structure of the investigated membrane material. The data presented here strike this concepts in case of hemophane. Two commercially available hemophane dialyzers, the GF MC 120 (Gambro) and the MO 450 (SMAD) membranes, were compared. Significant differences could be seen in the induction of leukopenia and leukocyte sequestration reaction within patients lungs, but also in capacity to influence granulocyte oxidative metabolism and release of granular enzymes. According to these data it seems questionable whether hemophane is a membrane material with constant structure and quality normally expected for products bearing trade names. Excluding other differences (like surface-area or sterilization method) variable amounts of DEAE substituents and/or an inconstant distribution of the DEAE groups within the membranes may be the most possible reason responsible for the differences found. The study underlines the urgent need of an exact physico-chemical characterization of dialyzer membranes and is therefore a challenge for free publication of such basic data by the producers.

Medienart:

Artikel

Erscheinungsjahr:

1992

Erschienen:

1992

Enthalten in:

Zur Gesamtaufnahme - volume:20

Enthalten in:

Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology - 20(1992), 5 vom: 15., Seite 1233-48

Sprache:

Englisch

Beteiligte Personen:

Kolb, G [VerfasserIn]
Müller, T [VerfasserIn]
Höffken, H [VerfasserIn]
Joseph, K [VerfasserIn]
Lange, H [VerfasserIn]
Havemann, K [VerfasserIn]

Themen:

106254-94-8
2-diethylaminoethanol
9004-34-6
Biocompatible Materials
Cellulose
EC 1.11.1.7
EC 3.4.21.36
EC 3.4.21.37
Ethanolamines
Hemophan
Journal Article
Leukocyte Elastase
Membranes, Artificial
Pancreatic Elastase
Peroxidase
Reactive Oxygen Species
S6DL4M053U

Anmerkungen:

Date Completed 14.01.1993

Date Revised 28.10.2019

published: Print

Citation Status MEDLINE

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM013150847